Water deprivation does not augment sympathetic or pressor responses to sciatic afferent nerve stimulation in rats or to static exercise in humans.
Animals
Blood Pressure
/ physiology
Dehydration
/ blood
Exercise
/ physiology
Glutamic Acid
/ metabolism
Humans
Male
Medulla Oblongata
/ drug effects
Physical Conditioning, Animal
/ physiology
Rats
Rats, Sprague-Dawley
Sciatic Nerve
/ drug effects
Sodium
/ blood
Sympathetic Nervous System
/ drug effects
Vasoconstrictor Agents
/ pharmacology
Water Deprivation
/ physiology
exercise pressor reflex
hypernatremia
hypohydration
sciatic nerve stimulation
sympathetic nerve activity
Journal
Journal of applied physiology (Bethesda, Md. : 1985)
ISSN: 1522-1601
Titre abrégé: J Appl Physiol (1985)
Pays: United States
ID NLM: 8502536
Informations de publication
Date de publication:
01 07 2019
01 07 2019
Historique:
pubmed:
10
5
2019
medline:
30
9
2020
entrez:
10
5
2019
Statut:
ppublish
Résumé
Excess dietary salt intake excites central sympathetic networks, which may be related to plasma hypernatremia. Plasma hypernatremia also occurs following water deprivation (WD). The purpose of this study was to test the hypothesis that WD induces hypernatremia and consequently augments sympathetic and pressor responses to sympathoexcitatory stimuli in rats and humans. Sympathetic nerve activity (SNA) and arterial blood pressure (ABP) responses to sciatic afferent nerve stimulation (2-20 Hz) and chemical stimulation of the rostral ventrolateral medulla (RVLM) were assessed in rats after 48 h of WD and compared with normally hydrated control rats (CON). In a parallel randomized-crossover human experiment (
Identifiants
pubmed: 31070954
doi: 10.1152/japplphysiol.00005.2019
pmc: PMC6692747
doi:
Substances chimiques
Vasoconstrictor Agents
0
Glutamic Acid
3KX376GY7L
Sodium
9NEZ333N27
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
235-245Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM113125
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL128388
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL113270
Pays : United States
Références
J Physiol. 1999 Jun 1;517 ( Pt 2):477-94
pubmed: 10332096
Am J Physiol. 1999 Jun;276(6):R1600-7
pubmed: 10362737
J Appl Physiol (1985). 1999 Sep;87(3):1016-25
pubmed: 10484572
Am J Epidemiol. 2002 May 1;155(9):827-33
pubmed: 11978586
Blood Press Monit. 2003 Feb;8(1):27-30
pubmed: 12604933
Auton Neurosci. 2003 Sep 30;107(2):85-98
pubmed: 12963419
Clin Sci. 1964 Oct;27:229-44
pubmed: 14220903
J Physiol. 2003 Oct 15;552(Pt 2):635-44
pubmed: 14561843
Eur J Clin Nutr. 2003 Dec;57 Suppl 2:S24-9
pubmed: 14681710
Am J Physiol Heart Circ Physiol. 2004 May;286(5):H1642-8
pubmed: 14715511
Am J Physiol Regul Integr Comp Physiol. 2005 May;288(5):R1248-55
pubmed: 15661967
Am J Physiol Regul Integr Comp Physiol. 2005 Jul;289(1):R275-80
pubmed: 15845879
Med Sci Sports Exerc. 1992 Jun;24(6):657-70
pubmed: 1602938
Nat Rev Neurosci. 2006 May;7(5):335-46
pubmed: 16760914
Hypertension. 2007 Aug;50(2):354-9
pubmed: 17592069
J Am Coll Nutr. 2007 Oct;26(5 Suppl):535S-541S
pubmed: 17921462
J Am Coll Nutr. 2007 Oct;26(5 Suppl):542S-548S
pubmed: 17921463
Hypertension. 2008 Nov;52(5):932-7
pubmed: 18779436
Hypertension. 2009 Aug;54(2):308-14
pubmed: 19506102
J Physiol. 2009 Nov 15;587(Pt 22):5441-9
pubmed: 19805740
Diabetes Care. 2011 Dec;34(12):2551-4
pubmed: 21994426
Exp Physiol. 2012 Mar;97(3):327-32
pubmed: 22143882
Med Sci Sports Exerc. 2013 Sep;45(9):1782-9
pubmed: 23470313
Am J Physiol Heart Circ Physiol. 2014 Feb;306(3):H450-4
pubmed: 24271488
Compr Physiol. 2014 Jan;4(1):257-85
pubmed: 24692140
Hypertension. 2014 Sep;64(3):583-9
pubmed: 24914195
Clin J Am Soc Nephrol. 2015 May 7;10(5):852-62
pubmed: 25078421
J Sports Sci. 2015;33(18):1962-9
pubmed: 25793570
J Clin Hypertens (Greenwich). 2015 Nov;17(11):837-44
pubmed: 26235814
Exp Physiol. 2016 Jan;101(1):135-42
pubmed: 26374269
Hypertension. 2015 Dec;66(6):1184-90
pubmed: 26416846
J Am Coll Cardiol. 2015 Oct 20;66(16):1843-1845
pubmed: 26483112
Eur J Nutr. 2017 Apr;56(3):1211-1217
pubmed: 26864199
Biol Sport. 2016 Sep;33(3):291-6
pubmed: 27601785
Hypertension. 2017 Jan;69(1):163-170
pubmed: 27895193
J Neurophysiol. 2017 Oct 1;118(4):2232-2237
pubmed: 28747468
Physiol Behav. 2018 Mar 1;185:103-111
pubmed: 29277553
J Neurophysiol. 2018 Apr 1;119(4):1257-1265
pubmed: 29357474
Med Sci Sports Exerc. 2018 Aug;50(8):1697-1703
pubmed: 29509643
J Appl Physiol. 1974 Aug;37(2):247-8
pubmed: 4850854
J Physiol. 1971 Jul;215(3):789-804
pubmed: 5090995
N Engl J Med. 1984 Sep 20;311(12):753-9
pubmed: 6472364
J Auton Nerv Syst. 1993 Jun;43(3):231-9
pubmed: 7690055
Hypertension. 1993 Dec;22(6):929-33
pubmed: 7902336
Am J Physiol. 1994 Oct;267(4 Pt 2):H1549-56
pubmed: 7943401
Hypertension. 1993 Oct;22(4):479-85
pubmed: 8406652
J Appl Physiol (1985). 1995 Nov;79(5):1487-96
pubmed: 8594004