Circulating transforming growth factor-β1 facilitates remyelination in the adult central nervous system.
Adult
Animals
Cells, Cultured
Central Nervous System
/ drug effects
Demyelinating Diseases
/ chemically induced
Disease Models, Animal
Humans
Mice
Multiple Sclerosis
/ drug therapy
Oligodendroglia
/ drug effects
Remyelination
/ drug effects
Transforming Growth Factor beta1
/ administration & dosage
Treatment Outcome
brain
human
mouse
neuroscience
spinal cord
systemic environment
white matter
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
09 05 2019
09 05 2019
Historique:
received:
10
09
2018
accepted:
26
04
2019
entrez:
10
5
2019
pubmed:
10
5
2019
medline:
26
2
2020
Statut:
epublish
Résumé
Oligodendrocyte maturation is necessary for functional regeneration in the CNS; however, the mechanisms by which the systemic environment regulates oligodendrocyte maturation is unclear. We found that Transforming growth factor (TGF)-β1, which is present in higher levels in the systemic environment, promotes oligodendrocyte maturation. Oligodendrocyte maturation was enhanced by adult mouse serum treatment via TGF-β type I receptor. Decrease in circulating TGF-β1 level prevented remyelination in the spinal cord after toxin-induced demyelination. TGF-β1 administration promoted remyelination and restored neurological function in a multiple sclerosis animal model. Furthermore, TGF-β1 treatment stimulated human oligodendrocyte maturation. These data provide the therapeutic possibility of TGF-β for demyelinating diseases.
Identifiants
pubmed: 31071011
doi: 10.7554/eLife.41869
pii: 41869
pmc: PMC6508935
doi:
pii:
Substances chimiques
Transforming Growth Factor beta1
0
Banques de données
Dryad
['10.5061/dryad.nj51t60']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Japan Society for the Promotion of Science
ID : 16H04672
Pays : International
Organisme : The Uehara Memorial Foundation
ID : 2017
Pays : International
Organisme : Japan Society for the Promotion of Science
ID : 17H06178
Pays : International
Organisme : Japan Society for the Promotion of Science
ID : 19H03554
Pays : International
Informations de copyright
© 2019, Hamaguchi et al.
Déclaration de conflit d'intérêts
MH, RM, HF, HM, HK, TY No competing interests declared
Références
Neurobiol Aging. 2002 Mar-Apr;23(2):237-43
pubmed: 11804709
Nat Med. 2006 Sep;12(9):1005-15
pubmed: 16960575
Immunol Lett. 1994 Jul;41(2-3):279-86
pubmed: 8002051
J Pathol. 2003 Oct;201(2):319-27
pubmed: 14517850
Cell. 2003 Oct 17;115(2):163-75
pubmed: 14567914
Mol Cell Neurosci. 2003 Oct;24(2):476-88
pubmed: 14572468
Hepatology. 2007 Feb;45(2):369-76
pubmed: 17256748
Neuron. 2017 May 17;94(4):759-773.e8
pubmed: 28521131
J Biol Chem. 2015 May 1;290(18):11515-25
pubmed: 25795781
J Neurosci. 2014 Jun 4;34(23):7917-30
pubmed: 24899714
Nat Commun. 2018 Feb 7;9(1):551
pubmed: 29416028
Blood. 2003 Nov 1;102(9):3129-35
pubmed: 12842983
Nat Med. 2011 Jul 07;17(7):796-808
pubmed: 21738161
Science. 2014 May 9;344(6184):649-52
pubmed: 24797481
Neuron. 2008 Jan 24;57(2):178-201
pubmed: 18215617
Nature. 2015 Jun 11;522(7555):216-20
pubmed: 25896324
Cell. 2013 May 9;153(4):828-39
pubmed: 23663781
Glia. 2014 Feb;62(2):272-83
pubmed: 24310780
J Neurosci. 1998 Jan 15;18(2):601-9
pubmed: 9425002
Neurosci Lett. 2013 Aug 29;550:60-3
pubmed: 23827227
Proc Natl Acad Sci U S A. 1991 Apr 1;88(7):2918-21
pubmed: 2011600
Biomaterials. 2003 Jul;24(15):2593-603
pubmed: 12726713
Glia. 1999 Oct;28(1):77-83
pubmed: 10498825
Cell Stem Cell. 2012 Jan 6;10(1):96-103
pubmed: 22226359
J Neuropathol Exp Neurol. 1999 Feb;58(2):174-87
pubmed: 10029100
Nat Med. 2002 Oct;8(10):1115-21
pubmed: 12357247
Ann Neurol. 1994;36 Suppl:S42-6
pubmed: 8017888
Nat Med. 2014 Jun;20(6):659-63
pubmed: 24793238
J Mol Med (Berl). 1997 Mar;75(3):165-73
pubmed: 9106073
Cytokine Growth Factor Rev. 2000 Mar-Jun;11(1-2):133-45
pubmed: 10708961
N Engl J Med. 2002 Jan 17;346(3):165-73
pubmed: 11796850
J Clin Invest. 2007 Nov;117(11):3306-15
pubmed: 17965773
Nat Rev Neurosci. 2017 Nov 16;18(12):753-769
pubmed: 29142295
J Neurosci Res. 1995 Apr 1;40(5):579-90
pubmed: 7602612
J Clin Invest. 2017 Sep 1;127(9):3496-3509
pubmed: 28825598
Elife. 2019 May 09;8:
pubmed: 31071011
Nat Med. 2007 Feb;13(2):204-10
pubmed: 17237794
Nat Rev Neurosci. 2002 Sep;3(9):705-14
pubmed: 12209119
Nature. 2011 Aug 31;477(7362):90-4
pubmed: 21886162
Science. 2014 May 9;344(6184):630-4
pubmed: 24797482
Front Cell Neurosci. 2013 Dec 20;7:268
pubmed: 24391545