Adult-born hippocampal neurons bidirectionally modulate entorhinal inputs into the dentate gyrus.
Journal
Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511
Informations de publication
Date de publication:
10 05 2019
10 05 2019
Historique:
received:
13
04
2018
accepted:
27
03
2019
entrez:
11
5
2019
pubmed:
11
5
2019
medline:
18
12
2019
Statut:
ppublish
Résumé
Young adult-born granule cells (abGCs) in the dentate gyrus (DG) have a profound impact on cognition and mood. However, it remains unclear how abGCs distinctively contribute to local DG information processing. We found that the actions of abGCs in the DG depend on the origin of incoming afferents. In response to lateral entorhinal cortex (LEC) inputs, abGCs exert monosynaptic inhibition of mature granule cells (mGCs) through group II metabotropic glutamate receptors. By contrast, in response to medial entorhinal cortex (MEC) inputs, abGCs directly excite mGCs through
Identifiants
pubmed: 31073064
pii: 364/6440/578
doi: 10.1126/science.aat8789
pmc: PMC6800071
mid: NIHMS1054573
doi:
Substances chimiques
Receptors, N-Methyl-D-Aspartate
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
578-583Subventions
Organisme : NIH HHS
ID : DP5 OD017908
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH068542
Pays : United States
Organisme : NIMHD NIH HHS
ID : G12 MD007599
Pays : United States
Organisme : NIMH NIH HHS
ID : R00 MH108719
Pays : United States
Organisme : NIA NIH HHS
ID : K01 AG054765
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH083862
Pays : United States
Organisme : NIH HHS
ID : S10 OD018464
Pays : United States
Organisme : NIMH NIH HHS
ID : R37 MH068542
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG043688
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS081203
Pays : United States
Organisme : NIMH NIH HHS
ID : K99 MH108719
Pays : United States
Commentaires et corrections
Type : CommentIn
Type : CommentIn
Informations de copyright
Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
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