Development, Validation of LC-MS/MS Method and Determination of Pharmacokinetic Parameters of the Stroke Neuroprotectant Neurounina-1 in Beagle Dog Plasma After Intravenous Administration.
LC-MS/MS
Na+/Ca2+ exchanger (NCX)
beagle dog plasma
neurounina-1
pharmacokinetics
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2019
2019
Historique:
received:
23
07
2018
accepted:
04
04
2019
entrez:
11
5
2019
pubmed:
11
5
2019
medline:
11
5
2019
Statut:
epublish
Résumé
Neurounina-1 [chemical name: 7-nitro-5-phenyl-1-(pyrrolidin-1-ylmethyl)-1H-benzo[e][1,4]diazepin-2(3H)-one] is a new compound provided with relevant neuroprotective effect during stroke and in neonatal hypoxia by increasing the Na
Identifiants
pubmed: 31073288
doi: 10.3389/fphar.2019.00432
pmc: PMC6497007
doi:
Types de publication
Journal Article
Langues
eng
Pagination
432Références
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