Conservative hysteroscopic treatment of stage I well differentiated endometrial cancer in patients with high surgical risk: a pilot study.
Aged
Aged, 80 and over
Antineoplastic Agents, Hormonal
/ administration & dosage
Carcinoma, Endometrioid
/ pathology
Endometrial Neoplasms
/ pathology
Female
Humans
Hysteroscopy
/ methods
Intrauterine Devices, Medicated
Levonorgestrel
/ administration & dosage
Longitudinal Studies
Middle Aged
Pilot Projects
Prospective Studies
Treatment Outcome
Endometrial Cancer
High Surgical Risk
Hysteroscopic Surgery
Obesity
Journal
Journal of gynecologic oncology
ISSN: 2005-0399
Titre abrégé: J Gynecol Oncol
Pays: Korea (South)
ID NLM: 101483150
Informations de publication
Date de publication:
Jul 2019
Jul 2019
Historique:
received:
19
10
2018
revised:
24
01
2019
accepted:
04
02
2019
pubmed:
11
5
2019
medline:
10
3
2020
entrez:
11
5
2019
Statut:
ppublish
Résumé
To report hysteroscopic treatment combined with levonorgestrel-releasing intrauterine device (LNG-IUD) to treat women with early well differentiated endometrial cancer (EC) at high surgical risk. Nine women diagnosed with stage IA, grade 1 endometrioid EC which was contraindicated or refused standard treatment with external beam radiation therapy with or without brachytherapy were enrolled in our prospective study. Endo-myometrial hysteroscopic resection of the whole uterine cavity and the placement of LNG-IUD for 5 years was performed. Response rate, perioperative complications, and recurrence of disease were evaluated. None had intra or post-operative complications and all were discharged no later than the third day of hospitalization. After 6 months from surgery, all the women showed a complete regression of the lesion. All the women completed the 5 years follow-up and in no case was detected sign of recurrence. Two women died for causes unrelated to the tumor or the ongoing therapy. The alternative treatment with endo-myometrial hysteroscopic resection and LNG-IUD in women with stage IA, grade 1 endometrioid EC showed initial encouraging outcomes in terms of effectiveness and safety.
Identifiants
pubmed: 31074243
pii: 30.e62
doi: 10.3802/jgo.2019.30.e62
pmc: PMC6543116
doi:
Substances chimiques
Antineoplastic Agents, Hormonal
0
Levonorgestrel
5W7SIA7YZW
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e62Informations de copyright
Copyright © 2019. Asian Society of Gynecologic Oncology, Korean Society of Gynecologic Oncology.
Déclaration de conflit d'intérêts
No potential conflict of interest relevant to this article was reported.
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