Seroepidemiology of Hepatitis B in the Democratic Republic of the Congo.
Adolescent
Adult
Child
Child, Preschool
Democratic Republic of the Congo
/ epidemiology
Female
Genotyping Techniques
Hepatitis B
/ epidemiology
Hepatitis B Surface Antigens
/ blood
Hepatitis B Vaccines
/ immunology
Hepatitis B virus
/ classification
Humans
Infant
Male
Prevalence
Seroepidemiologic Studies
Socioeconomic Factors
Vaccination
Young Adult
Journal
The American journal of tropical medicine and hygiene
ISSN: 1476-1645
Titre abrégé: Am J Trop Med Hyg
Pays: United States
ID NLM: 0370507
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
pubmed:
11
5
2019
medline:
22
1
2020
entrez:
11
5
2019
Statut:
ppublish
Résumé
Hepatitis B virus (HBV) is endemic throughout Africa, but its prevalence in the Democratic Republic of the Congo (DRC) is incompletely understood. We used dried blood spot (DBS) samples from the 2013 to 2014 Demographic and Health Survey in the DRC to measure the prevalence of HBV using the Abbott ARCHITECT HBV surface antigen (HBsAg) qualitative assay. We then attempted to sequence and genotype HBsAg-positive samples. The weighted national prevalence of HBV was 3.3% (95% CI: 1.8-4.7%), with a prevalence of 2.2% (95% CI: 0.3-4.1%) among children. Hepatitis B virus cases occurred countrywide and across age strata. Genotype E predominated (60%), and we found a unique cluster of genotype A isolates (30%). In conclusion, DBS-based HBsAg testing from a nationally representative survey found that HBV is common and widely distributed among Congolese adults and children. The distribution of cases across ages suggests ongoing transmission and underscores the need for additional interventions to prevent HBV infection.
Identifiants
pubmed: 31074406
doi: 10.4269/ajtmh.18-0883
pmc: PMC6609197
doi:
Substances chimiques
Hepatitis B Surface Antigens
0
Hepatitis B Vaccines
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
226-229Références
BMC Infect Dis. 2017 Nov 1;17(Suppl 1):700
pubmed: 29143672
J Clin Microbiol. 2017 May;55(5):1299-1312
pubmed: 28202798
BMC Res Notes. 2017 Dec 2;10(1):665
pubmed: 29197421
PLoS One. 2016 Nov 7;11(11):e0166201
pubmed: 27820845
World J Hepatol. 2015 Oct 18;7(23):2482-91
pubmed: 26483870
World J Gastroenterol. 2014 Jun 21;20(23):7152-68
pubmed: 24966586
J Med Virol. 2009 Mar;81(3):435-40
pubmed: 19152415
Infect Agent Cancer. 2016 Sep 15;11:51
pubmed: 27651827
J Infect Dis. 2004 Jul 15;190(2):400-8
pubmed: 15216479
J Clin Virol. 2015 Oct;71:10-7
pubmed: 26370308
Clin Infect Dis. 2018 Jan 6;66(2):254-260
pubmed: 29048459
Clin Infect Dis. 2017 Mar 15;64(6):796-803
pubmed: 28200031
J Med Virol. 2018 Feb;90(2):250-254
pubmed: 28460156