Gender differences of patients at-risk for psychosis regarding symptomatology, drug use, comorbidity and functioning - Results from the EU-GEI study.

Adolescent Adult Anxiety Disorders / epidemiology Comorbidity Early Diagnosis Europe / epidemiology Female Humans Male Psychotic Disorders / epidemiology Schizophrenia / diagnosis Sex Distribution Sex Factors Substance-Related Disorders / epidemiology Young Adult
Comorbidity Functioning Gender differences Risk for psychosis Sex differences

Journal

European psychiatry : the journal of the Association of European Psychiatrists
ISSN: 1778-3585
Titre abrégé: Eur Psychiatry
Pays: England
ID NLM: 9111820

Informations de publication

Date de publication:
06 2019
Historique:
received: 13 03 2019
revised: 25 04 2019
accepted: 26 04 2019
pubmed: 11 5 2019
medline: 16 7 2020
entrez: 11 5 2019
Statut: ppublish

Résumé

Gender differences in symptomatology in chronic schizophrenia and first episode psychosis patients have often been reported. However, little is known about gender differences in those at risk of psychotic disorders. This study investigated gender differences in symptomatology, drug use, comorbidity (i.e. substance use, affective and anxiety disorders) and global functioning in patients with an at-risk mental state (ARMS) for psychosis. The sample consisted of 336 ARMS patients (159 women) from the prodromal work package of the EUropean network of national schizophrenia networks studying Gene-Environment Interactions (EU-GEI; 11 centers). Clinical symptoms, drug use, comorbidity and functioning were assessed at first presentation to an early detection center using structured interviews. In unadjusted analyses, men were found to have significantly higher rates of negative symptoms and current cannabis use while women showed higher rates of general psychopathology and more often displayed comorbid affective and anxiety disorders. No gender differences were found for global functioning. The results generally did not change when corrected for possible cofounders (e.g. cannabis use). However, most differences did not withstand correction for multiple testing. Findings indicate that gender differences in symptomatology and comorbidity in ARMS are similar to those seen in overt psychosis and in healthy controls. However, observed differences are small and would only be reliably detected in studies with high statistical power. Moreover, such small effects would likely not be clinically meaningful.

Sections du résumé

BACKGROUND
Gender differences in symptomatology in chronic schizophrenia and first episode psychosis patients have often been reported. However, little is known about gender differences in those at risk of psychotic disorders. This study investigated gender differences in symptomatology, drug use, comorbidity (i.e. substance use, affective and anxiety disorders) and global functioning in patients with an at-risk mental state (ARMS) for psychosis.
METHODS
The sample consisted of 336 ARMS patients (159 women) from the prodromal work package of the EUropean network of national schizophrenia networks studying Gene-Environment Interactions (EU-GEI; 11 centers). Clinical symptoms, drug use, comorbidity and functioning were assessed at first presentation to an early detection center using structured interviews.
RESULTS
In unadjusted analyses, men were found to have significantly higher rates of negative symptoms and current cannabis use while women showed higher rates of general psychopathology and more often displayed comorbid affective and anxiety disorders. No gender differences were found for global functioning. The results generally did not change when corrected for possible cofounders (e.g. cannabis use). However, most differences did not withstand correction for multiple testing.
CONCLUSIONS
Findings indicate that gender differences in symptomatology and comorbidity in ARMS are similar to those seen in overt psychosis and in healthy controls. However, observed differences are small and would only be reliably detected in studies with high statistical power. Moreover, such small effects would likely not be clinically meaningful.

Identifiants

DOI: 10.1016/j.eurpsy.2019.04.007 PMID: 31075522
pubmed: 31075522
pii: S0924-9338(19)30077-X
doi: 10.1016/j.eurpsy.2019.04.007
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

52-59

Subventions

Organisme : Medical Research Council
ID : MR/J008915/1
Pays : United Kingdom

Informations de copyright

Copyright © 2019. Published by Elsevier Masson SAS.

Auteurs

Stephanie Menghini-Müller (S)

Center for Gender Research and Early Detection, University of Basel Psychiatric Hospital, Basel, Switzerland; University of Basel, Department of Psychology, Division of Clinical Psychology and Epidemiology, Basel, Switzerland.

Erich Studerus (E)

Center for Gender Research and Early Detection, University of Basel Psychiatric Hospital, Basel, Switzerland.

Sarah Ittig (S)

Center for Gender Research and Early Detection, University of Basel Psychiatric Hospital, Basel, Switzerland.

Ulrike Heitz (U)

Center for Gender Research and Early Detection, University of Basel Psychiatric Hospital, Basel, Switzerland.

Laura Egloff (L)

Center for Gender Research and Early Detection, University of Basel Psychiatric Hospital, Basel, Switzerland.

Christina Andreou (C)

Center for Gender Research and Early Detection, University of Basel Psychiatric Hospital, Basel, Switzerland.

Lucia R Valmaggia (LR)

Department of Psychology, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.

Matthew J Kempton (MJ)

Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.

Mark van der Gaag (M)

VU University, Faculty of Behavioural and Movement Sciences, Department of Clinical Psychology and EMGO+ Institute for Health Care Research, Amsterdam, the Netherlands; Parnassia Psychiatric Institute, Department of Psychosis Research, The Hague, the Netherlands.

Lieuwe de Haan (L)

AMC, Academic Psychiatric Centre, Department Early Psychosis, Amsterdam, the Netherlands; Arkin, Amsterdam, the Netherlands.

Barnaby Nelson (B)

Centre for Youth Mental Health, University of Melbourne, Melbourne, Australia.

Neus Barrantes-Vidal (N)

Departament de Psicologia Clínica I de la Salut (Universitat Autònoma de Barcelona), Fundació Sanitària Sant Pere Claver (Spain), Spanish Mental Health Research Network (CIBERSAM), Spain.

Merete Nordentoft (M)

Mental Health Center Copenhagen, Mental Health Services in the Capital Region of Denmark, Denmark; Institute for Clinical Medicine, Faculty of Health Science, University of Copenhagen, Denmark.

Stephan Ruhrmann (S)

Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany.

Gabriele Sachs (G)

Medical University of Vienna, Department of Psychiatry and Psychotherapy, Austria.

Bart P Rutten (BP)

Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht, the Netherlands.

Jim van Os (JV)

Department Psychiatry, Brain Centre Rudolf Magnus, Utrecht University Medical Centre, Utrecht, the Netherlands; Department of Psychiatry and Psychology, School for Mental Health and Neuroscience (MHeNS), Maastricht University Medical Centre, Maastricht, the Netherlands; King's College London, King's Health Partners Department of Psychosis Studies, Institute of Psychiatry, London, United Kingdom.

Anita Riecher-Rössler (A)

Center for Gender Research and Early Detection, University of Basel Psychiatric Hospital, Basel, Switzerland. Electronic address: anita.riecher@upk.ch.

Philip McGuire (P)

Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, Denmark 458 Hill, SE5 8AF London, United Kingdom.

Lucia R Valmaggia (LR)

Department of Psychology, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, Denmark Hill, 456 SE5 8AF London, United Kingdom.

Matthew J Kempton (MJ)

Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, Denmark 458 Hill, SE5 8AF London, United Kingdom.

Maria Calem (M)

Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, Denmark 458 Hill, SE5 8AF London, United Kingdom.

Stefania Tognin (S)

Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, Denmark 458 Hill, SE5 8AF London, United Kingdom.

Gemma Modinos (G)

Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, Denmark 458 Hill, SE5 8AF London, United Kingdom.

Lieuwe de Haan (L)

Amsterdam UMC, University of Amsterdam, Psychiatry, Department Early Psychosis, Meibergdreef 9, Amsterdam, The Netherlands; Arkin Amsterdam.

Mark van der Gaag (M)

VU University, Faculty of Behavioural and Movement Sciences, Department of Clinical Psychology and Amsterdam Public Mental Health research institute, van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands; Mental Health Institute Noord-Holland Noord, Hoorn, The Netherlands; Parnassia Psychiatric Institute, Department of Psychosis Research, Zoutkeetsingel 40, 2512 HNThe Hague, The Netherlands.

Eva Velthorst (E)

Department of Psychiatry and Seaver Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, NY, US; Early Psychosis Section, Department of Psychiatry, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.

Tamar C Kraan (TC)

Mental Health Institute Arkin, Amsterdam, The Netherlands.

Daniella S van Dam (DS)

Amsterdam UMC, University of Amsterdam, Psychiatry, Department Early Psychosis, Meibergdreef 9, Amsterdam, The Netherlands.

Nadine Burger (N)

Arkin Amsterdam.

Barnaby Nelson (B)

Orygen, The National Centre of Excellence in Youth Mental Health, University of Melbourne; Centre for Youth Mental Health, University of Melbourne, 35 Poplar Road (Locked Bag 10), Parkville, Victoria 485 3052, Australia.

Patrick McGorry (P)

Orygen, The National Centre of Excellence in Youth Mental Health, University of Melbourne; Centre for Youth Mental Health, University of Melbourne, 35 Poplar Road (Locked Bag 10), Parkville, Victoria 485 3052, Australia.

G Paul Amminger (GP)

Orygen, The National Centre of Excellence in Youth Mental Health, University of Melbourne; Centre for Youth Mental Health, University of Melbourne, 35 Poplar Road (Locked Bag 10), Parkville, Victoria 485 3052, Australia.

Christos Pantelis (C)

Melbourne Neuropsychiatry Centre, The University of Melbourne.

Athena Politis (A)

Orygen, The National Centre of Excellence in Youth Mental Health, University of Melbourne; Centre for Youth Mental Health, University of Melbourne, 35 Poplar Road (Locked Bag 10), Parkville, Victoria 485 3052, Australia.

Joanne Goodall (J)

Orygen, The National Centre of Excellence in Youth Mental Health, University of Melbourne; Centre for Youth Mental Health, University of Melbourne, 35 Poplar Road (Locked Bag 10), Parkville, Victoria 485 3052, Australia.

Anita Riecher-Rössler (A)

University Psychiatric Hospital, Wilhelm Klein-Strasse 27, CH-4002 Basel, Switzerland.

Stefan Borgwardt (S)

University Psychiatric Hospital, Wilhelm Klein-Strasse 27, CH-4002 Basel, Switzerland.

Charlotte Rapp (C)

University Psychiatric Hospital, Wilhelm Klein-Strasse 27, CH-4002 Basel, Switzerland.

Sarah Ittig (S)

University Psychiatric Hospital, Wilhelm Klein-Strasse 27, CH-4002 Basel, Switzerland.

Erich Studerus (E)

University Psychiatric Hospital, Wilhelm Klein-Strasse 27, CH-4002 Basel, Switzerland.

Renata Smieskova (R)

University Psychiatric Hospital, Wilhelm Klein-Strasse 27, CH-4002 Basel, Switzerland.

Rodrigo Bressan (R)

LiNC - Lab Interdisciplinar Neurociôncias Clínicas, Depto Psiquiatria, Escola Paulista de Medicina, Universidade Federal de São Paulo - UNIFESP.

Ary Gadelha (A)

LiNC - Lab Interdisciplinar Neurociôncias Clínicas, Depto Psiquiatria, Escola Paulista de Medicina, Universidade Federal de São Paulo - UNIFESP.

Elisa Brietzke (E)

Depto Psiquiatria, Escola Paulista de Medicina, Universidade Federal de São Paulo - UNIFESP.

Graccielle Asevedo (G)

LiNC - Lab Interdisciplinar Neurociôncias Clínicas, Depto Psiquiatria, Escola Paulista de Medicina, Universidade Federal de São Paulo - UNIFESP.

Elson Asevedo (E)

LiNC - Lab Interdisciplinar Neurociôncias Clínicas, Depto Psiquiatria, Escola Paulista de Medicina, Universidade Federal de São Paulo - UNIFESP.

Andre Zugman (A)

LiNC - Lab Interdisciplinar Neurociôncias Clínicas, Depto Psiquiatria, Escola Paulista de Medicina, Universidade Federal de São Paulo - UNIFESP.

Neus Barrantes-Vidal (N)

Departament de Psicologia Clínica i de la Salut (Universitat Autònoma de Barcelona), Fundació Sanitària Sant Pere Claver (Spain), Spanish Mental Health Research Network (CIBERSAM).

Tecelli Domínguez-Martínez (T)

CONACYT-Dirección de Investigaciones Epidemiológicas y Psicosociales, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz (México).

Anna Racioppi (A)

Departament de Psicologia Clínica i de la Salut (Universitat Autònoma de Barcelona).

Paula Cristóbal-Narváez (P)

Departament de Psicologia Clínica i de la Salut (Universitat Autònoma de Barcelona).

Thomas R Kwapil (TR)

Department of Psychology, University of Illinois at Urbana-Champaign (USA).

Manel Monsonet (M)

Departament de Psicologia Clínica i de la Salut (Universitat Autònoma de Barcelona).

Mathilde Kazes (M)

University Paris Descartes, Hôpital Sainte-Anne, C'JAAD, Service Hospitalo-Universitaire, Inserm U894, Institut de Psychiatrie (CNRS 3557) Paris, France.

Claire Daban (C)

University Paris Descartes, Hôpital Sainte-Anne, C'JAAD, Service Hospitalo-Universitaire, Inserm U894, Institut de Psychiatrie (CNRS 3557) Paris, France.

Julie Bourgin (J)

University Paris Descartes, Hôpital Sainte-Anne, C'JAAD, Service Hospitalo-Universitaire, Inserm U894, Institut de Psychiatrie (CNRS 3557) Paris, France.

Olivier Gay (O)

University Paris Descartes, Hôpital Sainte-Anne, C'JAAD, Service Hospitalo-Universitaire, Inserm U894, Institut de Psychiatrie (CNRS 3557) Paris, France.

Célia Mam-Lam-Fook (C)

University Paris Descartes, Hôpital Sainte-Anne, C'JAAD, Service Hospitalo-Universitaire, Inserm U894, Institut de Psychiatrie (CNRS 3557) Paris, France.

Marie-Odile Krebs (MO)

University Paris Descartes, Hôpital Sainte-Anne, C'JAAD, Service Hospitalo-Universitaire, Inserm U894, Institut de Psychiatrie (CNRS 3557) Paris, France.

Dorte Nordholm (D)

Mental Health Center Copenhagen and Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, CINS, Mental Health Center Glostrup, Mental Health Services in the Capital Region of Copenhagen, University of Copenhagen.

Lasse Randers (L)

Mental Health Center Copenhagen and Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, CINS, Mental Health Center Glostrup, Mental Health Services in the Capital Region of Copenhagen, University of Copenhagen.

Kristine Krakauer (K)

Mental Health Center Copenhagen and Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, CINS, Mental Health Center Glostrup, Mental Health Services in the Capital Region of Copenhagen, University of Copenhagen.

Louise Glenthøj (L)

Mental Health Center Copenhagen and Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, CINS, Mental Health Center Glostrup, Mental Health Services in the Capital Region of Copenhagen, University of Copenhagen.

Birte Glenthøj (B)

Centre for Neuropsychiatric Schizophrenia Research (CNSR) & Centre for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Centre Glostrup, University of Copenhagen, Glostrup, Denmark.

Merete Nordentoft (M)

Mental Health Center Copenhagen and Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, CINS, Mental Health Center Glostrup, Mental Health Services in the Capital Region of Copenhagen, University of Copenhagen.

Stephan Ruhrmann (S)

Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany.

Dominika Gebhard (D)

Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany.

Julia Arnhold (J)

Psyberlin, Berlin, Germany.

Joachim Klosterkötter (J)

Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany.

Gabriele Sachs (G)

Medical University of Vienna, Department of Psychiatry and Psychotherapy.

Iris Lasser (I)

Medical University of Vienna, Department of Psychiatry and Psychotherapy.

Bernadette Winklbaur (B)

Medical University of Vienna, Department of Psychiatry and Psychotherapy.

Philippe A Delespaul (PA)

Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, P.O. Box 616, 6200 MD 464 Maastricht, The Netherlands; Mondriaan Mental Health Trust, P.O. Box 4436 CX Heerlen, The Netherlands.

Bart P Rutten (BP)

Medical University of Vienna, Department of Psychiatry and Psychotherapy.

Jim van Os (J)

Medical University of Vienna, Department of Psychiatry and Psychotherapy; Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, Denmark 458 Hill, SE5 8AF London, United Kingdom.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adolescent › Gender differences of patients at-risk for...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Gender differences of patients at-risk for...
questionsmedicales.fr › Troubles mentaux › Troubles anxieux › Gender differences of patients at-risk for...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Facteurs épidémiologiques › Comorbidité › Gender differences of patients at-risk for...
questionsmedicales.fr › Diagnostic › Diagnostic précoce › Gender differences of patients at-risk for...
questionsmedicales.fr › Régions géographiques › Europe › Gender differences of patients at-risk for...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Gender differences of patients at-risk for...
questionsmedicales.fr › Troubles mentaux › Schizophrénie et troubles avec traits psychotiques › Troubles psychotiques › Gender differences of patients at-risk for...
questionsmedicales.fr › Troubles mentaux › Schizophrénie et troubles avec traits psychotiques › Schizophrénie › Gender differences of patients at-risk for...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Mesures épidémiologiques › Démographie › Répartition par sexe › Gender differences of patients at-risk for...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Facteurs épidémiologiques › Facteurs sexuels › Gender differences of patients at-risk for...
questionsmedicales.fr › Troubles mentaux › Troubles liés à une substance › Gender differences of patients at-risk for...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Jeune adulte › Gender differences of patients at-risk for...