Efficacy of pharmacotherapy for OSA in adults: A systematic review and network meta-analysis.

Adult Drug Therapy Humans Network Meta-Analysis Randomized Controlled Trials as Topic Sleep Apnea, Obstructive / drug therapy
Drug Meta-analysis Obstructive sleep apnoea Pharmacotherapy Randomised controlled trial

Journal

Sleep medicine reviews
ISSN: 1532-2955
Titre abrégé: Sleep Med Rev
Pays: England
ID NLM: 9804678

Informations de publication

Date de publication:
08 2019
Historique:
received: 04 03 2019
revised: 11 04 2019
accepted: 16 04 2019
pubmed: 11 5 2019
medline: 6 5 2020
entrez: 11 5 2019
Statut: ppublish

Résumé

Pharmacotherapy represents a desirable potential therapeutic alternative for patients with obstructive sleep apnoea (OSA). We aimed to summarize evidence on the efficacy of pharmacotherapy in adults with OSA and delineate the underlying mechanisms. Seven databases were systematically screened for randomised controlled trials (RCTs) from their inception to September 2018. According to a pre-registered study protocol (PROSPERO-ID-CRD42018086446) network meta-analysis was performed to obtain intervention effects on the apnoea-hypopnoea-index (AHI) based on data extracted from published reports. We identified 58 RCTs (n = 1710 patients) investigating 44 different drugs or drug-combinations. Interventions were classified into seven pathomechanism-groups and summarized narratively. A meta-analysis of 17 trials for seven drugs (acetazolamide, donepezil, mirtazapine, ondansetron, paroxetine, protriptyline, theophylline) indicated a small effect for acetazolamide (mean difference in AHI -9.6/h [-17.7; -1.4]; p = 0.02). In the network meta-analysis (I

Identifiants

DOI: 10.1016/j.smrv.2019.04.009 PMID: 31075665
pubmed: 31075665
pii: S1087-0792(19)30050-4
doi: 10.1016/j.smrv.2019.04.009
pii:
doi:

Types de publication

Journal Article Systematic Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

74-86

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

Auteurs

Thomas Gaisl (T)

Department of Pulmonology, University Hospital Zurich, Zurich, Switzerland.

Sarah R Haile (SR)

Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland.

Sira Thiel (S)

Department of Pulmonology, University Hospital Zurich, Zurich, Switzerland.

Martin Osswald (M)

Department of Pulmonology, University Hospital Zurich, Zurich, Switzerland.

Malcolm Kohler (M)

Department of Pulmonology, University Hospital Zurich, Zurich, Switzerland. Electronic address: malcolm.kohler@usz.ch.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Efficacy of pharmacotherapy for OSA in adults:...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Efficacy of pharmacotherapy for OSA in adults:...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Efficacy of pharmacotherapy for OSA in adults:...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Méta-analyse comme sujet › Méta-analyse en réseau › Efficacy of pharmacotherapy for OSA in adults:...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études cliniques comme sujet › Essais cliniques comme sujet › Essais cliniques contrôlés comme sujet › Essais contrôlés randomisés comme sujet › Efficacy of pharmacotherapy for OSA in adults:...
questionsmedicales.fr › Maladies du système nerveux › Syndromes d'apnées du sommeil › Syndrome d'apnées obstructives du sommeil › Efficacy of pharmacotherapy for OSA in adults:...