Childhood infectious diseases and risk of non-Hodgkin's lymphoma according to the WHO classification: A reanalysis of the Italian multicenter case-control study.
Adolescent
Adult
Aged
Case-Control Studies
Chickenpox
/ epidemiology
Female
Humans
Incidence
Infections
/ epidemiology
Italy
/ epidemiology
Lymphoma, Non-Hodgkin
/ epidemiology
Male
Measles
/ epidemiology
Middle Aged
Mumps
/ epidemiology
Risk
Rubella
/ epidemiology
Whooping Cough
/ epidemiology
Young Adult
NHL subtypes
case-control study
childhood infections
Journal
International journal of cancer
ISSN: 1097-0215
Titre abrégé: Int J Cancer
Pays: United States
ID NLM: 0042124
Informations de publication
Date de publication:
15 02 2020
15 02 2020
Historique:
received:
26
11
2018
revised:
24
04
2019
accepted:
25
04
2019
pubmed:
12
5
2019
medline:
20
2
2020
entrez:
12
5
2019
Statut:
ppublish
Résumé
Since 1960, incidence of non-Hodgkin's lymphoma (NHL) has been increasing in most industrialized countries, but causes of this trend remain unclear. A role of the decreased exposure to infectious agents during childhood has been proposed. Our study evaluates the association between common childhood infectious diseases and the risk of NHL and its major subtypes by a reanalysis of the Italian multicenter case-control study. After exclusion of next-of-kin interviews, 1,193 cases, diagnosed between 1990 and 1993, and 1,708 population-based controls were included in the analyses. OR estimates were obtained by logistic regression, adjusting for gender, age, residence area, education, smoking habit and exposure to radiations, pesticides and aromatic hydrocarbons. Among B-cell lymphomas (n = 1,102) an inverse association was observed for rubella (OR = 0.80, 95% CI: 0.65-0.99), pertussis (OR = 0.74, 95% CI: 0.62-0.88) and any infection (OR = 0.75, 95% CI: 0.61-0.93). A negative trend by number of infections was observed, which was more evident among mature B-cell lymphoma (OR = 0.66 for three infections or more, 95% CI: 0.48-0.90). Our results indicate a potential protective role of common childhood infections in the etiology of B-cell NHL.
Types de publication
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
977-986Subventions
Organisme : Medical Research Council
ID : MR/S019669/1
Pays : United Kingdom
Organisme : American National Cancer Institute
ID : NCI CA51086
Pays : International
Informations de copyright
© 2019 UICC.
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