Dog ownership at three months of age is associated with protection against food allergy.
dogs
domestic pets
food allergy
microbiome
prevention
Journal
Allergy
ISSN: 1398-9995
Titre abrégé: Allergy
Pays: Denmark
ID NLM: 7804028
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
27
09
2018
revised:
19
03
2019
accepted:
22
03
2019
pubmed:
12
5
2019
medline:
4
9
2020
entrez:
12
5
2019
Statut:
ppublish
Résumé
The prevention of food allergy is a key priority for reducing the burden of allergic disease. Environmental exposures modulate the risk of developing food allergy and some of this may be mediated by the infants' developing microbiome. However, the role of potentially protective environmental exposures, such as pet ownership, is largely uninvestigated with respect to food allergy. We performed a secondary cohort analysis in the Enquiring About Tolerance (EAT) study, which enrolled 1303 three-month infants onto a randomized trial to prevent food allergy. A survey elicited domestic animal ownership and participants were examined for atopic dermatitis (AD) at enrolment. Sensitization to foods and aeroallergens were elicited by skin and serum testing at 3, 12 and 36 months. Food allergy status was determined by double-blind placebo-controlled food challenges between 1 and 3 years. Food allergy was diagnosed amongst 6.1% (68/1124) of participants with complete data. No significant relationships were demonstrated between food allergy and caesarean delivery, infections or antibiotic exposure in early life. After adjusting for familial atopic disease, maternal dog/cat sensitization and participant AD, living with dogs was associated with a 90% reduction in the odds of infants developing food allergy (adjusted odds ratio (aOR) 0.10 (confidence interval (CI) 0.01-0.71), P = 0.02). None of the 49 infants living with at least two dogs developed food allergy, suggesting a dose-response relationship (each dog owned aOR 0.12 (CI 0.02-0.81), P = 0.03). No relationship was demonstrated between owning dogs or cats and the development of AD. Dog ownership in infancy may prevent food allergy.
Sections du résumé
BACKGROUND
The prevention of food allergy is a key priority for reducing the burden of allergic disease. Environmental exposures modulate the risk of developing food allergy and some of this may be mediated by the infants' developing microbiome. However, the role of potentially protective environmental exposures, such as pet ownership, is largely uninvestigated with respect to food allergy.
METHODS
We performed a secondary cohort analysis in the Enquiring About Tolerance (EAT) study, which enrolled 1303 three-month infants onto a randomized trial to prevent food allergy. A survey elicited domestic animal ownership and participants were examined for atopic dermatitis (AD) at enrolment. Sensitization to foods and aeroallergens were elicited by skin and serum testing at 3, 12 and 36 months. Food allergy status was determined by double-blind placebo-controlled food challenges between 1 and 3 years.
RESULTS
Food allergy was diagnosed amongst 6.1% (68/1124) of participants with complete data. No significant relationships were demonstrated between food allergy and caesarean delivery, infections or antibiotic exposure in early life. After adjusting for familial atopic disease, maternal dog/cat sensitization and participant AD, living with dogs was associated with a 90% reduction in the odds of infants developing food allergy (adjusted odds ratio (aOR) 0.10 (confidence interval (CI) 0.01-0.71), P = 0.02). None of the 49 infants living with at least two dogs developed food allergy, suggesting a dose-response relationship (each dog owned aOR 0.12 (CI 0.02-0.81), P = 0.03). No relationship was demonstrated between owning dogs or cats and the development of AD.
CONCLUSION
Dog ownership in infancy may prevent food allergy.
Substances chimiques
Allergens
0
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2212-2219Subventions
Organisme : UK Food Standards Agency
ID : T07051
Pays : International
Organisme : Bioresources
ID : 090066/B/09/Z
Pays : International
Organisme : Wellcome Trust Strategic Award
ID : 098439/Z/12/Z
Pays : International
Organisme : Clinician Scientist Award from the UK National Institute for Health Research (NIHR)
ID : NIHRCS/01/2008/009
Pays : International
Organisme : Department of Health
ID : CDF-2014-07-037
Pays : United Kingdom
Organisme : Wellcome Trust Programme
ID : 092530/Z/10/Z
Pays : International
Organisme : Medical Research Council
ID : MC_G1001205
Pays : United Kingdom
Investigateurs
Louise Young
(L)
Victoria Offord
(V)
Mary DeSousa
(M)
Jason Cullen
(J)
Katherine Taylor
(K)
Anna Tseng
(A)
Bunmi Raji
(B)
Sarah Byrom
(S)
Gillian Regis
(G)
Charlie Bigwood
(C)
Charlotte Stedman
(C)
Sharon Tonner
(S)
Emily Banks
(E)
Yasmin Kahnum
(Y)
Rachel Babic
(R)
Ben Stockwell
(B)
Erin Thompson
(E)
Lorna Wheatley
(L)
Devi Patkunam
(D)
Kerry Richards
(K)
Ewa Pietraszewicz
(E)
Alick Stephens
(A)
Asha Sudra
(A)
Victor Turcanu
(V)
Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2019 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.
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