Solid stress, competition for space and cancer: The opposing roles of mechanical cell competition in tumour initiation and growth.
Apoptosis
Cancer
Cell competition
Epithelium
Mechanics
Mechanotransduction
Residual stress
Journal
Seminars in cancer biology
ISSN: 1096-3650
Titre abrégé: Semin Cancer Biol
Pays: England
ID NLM: 9010218
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
14
01
2019
revised:
23
04
2019
accepted:
07
05
2019
pubmed:
12
5
2019
medline:
30
9
2020
entrez:
12
5
2019
Statut:
ppublish
Résumé
The regulation of cell growth, cell proliferation and cell death is at the basis of the homeostasis of tissues. While they can be regulated by intrinsic and genetic factors, their response to external signals emanating from the local environment is also essential for tissue homeostasis. Tumour initiation and progression is based on the misregulation of growth, proliferation and death mostly through the accumulation of genetic mutations. Yet, there is an increasing body of evidences showing that tumour microenvironment also has a strong impact on cancer initiation and progression. This includes the mechanical constrains and the compressive forces generated by the resistance of the surrounding tissue/matrix to tumour expansion. Recently, mechanical stress has been proposed to promote competitive interactions between cells through a process called mechanical cell competition. Cell population with a high proliferative rate can compact and eliminate the neighbouring cells which are more sensitive to compaction. While this emerging concept has been recently validated in vivo, the relevance of this process during tumour progression has never been discussed extensively. In this review, I will first describe the phenomenology of mechanical cell competition focusing on the main parameters and the pathways regulating cell elimination. I will then discuss the relevance of mechanical cell competition in tumour initiation and expansion while emphasizing its potential opposing contributions to tumourogenesis.
Identifiants
pubmed: 31077845
pii: S1044-579X(19)30015-X
doi: 10.1016/j.semcancer.2019.05.004
pmc: PMC7221353
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
69-80Informations de copyright
Copyright © 2019 The Author. Published by Elsevier Ltd.. All rights reserved.
Références
Trends Cell Biol. 2016 Oct;26(10):776-788
pubmed: 27319281
Nat Rev Cancer. 2018 Dec;18(12):758-766
pubmed: 30420767
Curr Biol. 2016 Dec 5;26(23):3220-3229
pubmed: 27839970
Curr Biol. 2001 Nov 27;11(23):1847-57
pubmed: 11728307
Development. 2016 Feb 15;143(4):623-34
pubmed: 26811379
EMBO J. 2013 Oct 30;32(21):2790-803
pubmed: 24022370
Curr Biol. 2016 Feb 22;26(4):428-38
pubmed: 26853366
Nature. 1985 Oct 10-16;317(6037):555-8
pubmed: 4047173
Science. 2005 Mar 18;307(5716):1789-90
pubmed: 15774763
Nature. 2014 Oct 2;514(7520):54-8
pubmed: 25079331
Nat Rev Mol Cell Biol. 2013 Sep;14(9):581-91
pubmed: 23942450
Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15101-8
pubmed: 22932871
Nature. 2015 Sep 10;525(7568):261-4
pubmed: 26308893
Science. 2005 Mar 18;307(5716):1785-9
pubmed: 15774762
Cell. 2004 Apr 2;117(1):117-29
pubmed: 15066287
Philos Trans R Soc Lond B Biol Sci. 2015 Apr 19;370(1666):
pubmed: 25750242
Science. 2018 Nov 23;362(6417):911-917
pubmed: 30337457
Biophys J. 2014 Oct 21;107(8):1821-1828
pubmed: 25418163
Science. 1997 May 30;276(5317):1425-8
pubmed: 9162012
Mol Cell. 2013 Nov 21;52(4):529-40
pubmed: 24140422
Development. 2017 Dec 1;144(23):4238-4248
pubmed: 29183937
Nat Rev Mol Cell Biol. 2007 Aug;8(8):633-44
pubmed: 17643125
Nature. 2017 Apr 12;544(7649):212-216
pubmed: 28406198
Sci Rep. 2017 Sep 11;7(1):11157
pubmed: 28894191
Biosci Biotechnol Biochem. 2014;78(10):1631-9
pubmed: 25126715
Nat Rev Mol Cell Biol. 2006 Apr;7(4):265-75
pubmed: 16607289
Proc Natl Acad Sci U S A. 2016 Nov 8;113(45):E6974-E6983
pubmed: 27791172
Cell. 2017 Nov 30;171(6):1397-1410.e14
pubmed: 29107331
Nature. 2013 Aug 1;500(7460):39-44
pubmed: 23842495
Annu Rev Biomed Eng. 2014 Jul 11;16:321-46
pubmed: 25014786
EMBO Rep. 2015 Feb;16(2):250-7
pubmed: 25550404
Dev Growth Differ. 2018 Dec;60(9):522-530
pubmed: 30443922
Dev Cell. 2011 Aug 16;21(2):366-74
pubmed: 21839923
Cell. 2013 Aug 29;154(5):1047-1059
pubmed: 23954413
Nat Commun. 2014 Jul 31;5:4428
pubmed: 25079702
Cancer Res. 1988 May 1;48(9):2432-9
pubmed: 3356007
Nat Rev Mol Cell Biol. 2017 Dec;18(12):758-770
pubmed: 28951564
Science. 2015 May 22;348(6237):880-6
pubmed: 25999502
PLoS Comput Biol. 2017 Jul 13;13(7):e1005651
pubmed: 28704373
Nat Rev Cancer. 2008 Feb;8(2):141-7
pubmed: 18185517
Development. 1990 Dec;110(4):1001-20
pubmed: 2100251
Curr Biol. 2019 Jan 7;29(1):23-34.e8
pubmed: 30554899
Dev Cell. 2017 Nov 20;43(4):480-492.e6
pubmed: 29107560
J Cell Biol. 2013 Mar 18;200(6):689-98
pubmed: 23509066
Nature. 2011 Jun 08;474(7350):179-83
pubmed: 21654799
Curr Opin Cell Biol. 2017 Oct;48:106-112
pubmed: 28719866
Exp Cell Res. 1997 Aug 25;235(1):155-60
pubmed: 9281364
Nature. 2017 Feb 9;542(7640):246-250
pubmed: 28092921
Nature. 2017 Mar 2;543(7643):118-121
pubmed: 28199303
PLoS Comput Biol. 2014 Aug 28;10(8):e1003800
pubmed: 25167199
Dev Cell. 2017 Nov 6;43(3):305-317.e5
pubmed: 29112851
Biol Cell. 2019 Mar;111(3):51-66
pubmed: 30609052
Dev Biol. 1975 Feb;42(2):211-21
pubmed: 1116643
Dev Cell. 2002 Jun;2(6):797-805
pubmed: 12062091
Annu Rev Cell Dev Biol. 2016 Oct 6;32:411-439
pubmed: 27501445
Nature. 2018 Mar 1;555(7694):103-106
pubmed: 29414942
Dev Biol. 2009 Oct 1;334(1):161-73
pubmed: 19627985
Phys Biol. 2011 Apr;8(2):026014
pubmed: 21460431
Nat Biotechnol. 1997 Aug;15(8):778-83
pubmed: 9255794
Nat Biomed Eng. 2019 Mar;3(3):230-245
pubmed: 30948807
Curr Biol. 2009 Nov 17;19(21):1821-6
pubmed: 19853449
HFSP J. 2009 Aug;3(4):265-72
pubmed: 20119483
Cell Res. 2014 Nov;24(11):1299-310
pubmed: 25342560
Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):14843-8
pubmed: 23980147
Curr Biol. 2016 Feb 22;26(4):419-27
pubmed: 26853367
Dev Cell. 2017 Sep 25;42(6):585-599.e4
pubmed: 28919206
Nature. 2012 Apr 15;484(7395):546-9
pubmed: 22504183
Genetics. 2006 Apr;172(4):2093-100
pubmed: 16489229
J Cell Sci. 2008 Feb 1;121(Pt 3):290-7
pubmed: 18198188
Dev Biol. 1979 Mar;69(1):182-93
pubmed: 446891
PLoS Genet. 2010 Sep 23;6(9):e1001140
pubmed: 20885789
Genes Dev. 2007 Nov 1;21(21):2747-61
pubmed: 17974916
PLoS One. 2009;4(2):e4632
pubmed: 19247489
J Biochem. 2015 Jul;158(1):15-23
pubmed: 25991731
Clin Exp Metastasis. 2012 Aug;29(6):541-9
pubmed: 22476470
Nat Commun. 2016 Apr 25;7:11373
pubmed: 27109213
Dev Cell. 2018 Sep 24;46(6):706-719.e5
pubmed: 30146479
Science. 1976 Oct 1;194(4260):23-8
pubmed: 959840
Cell. 2007 Nov 30;131(5):966-79
pubmed: 18045538
Dev Cell. 2010 Jun 15;18(6):985-98
pubmed: 20627080
Nature. 1999 Jul 8;400(6740):166-9
pubmed: 10408443
Nat Med. 2011 Mar;17(3):320-9
pubmed: 21383745
Nature. 2015 Aug 27;524(7566):476-80
pubmed: 26287461
Curr Biol. 2018 Jul 9;28(13):2115-2128.e5
pubmed: 29910075
PLoS One. 2016 Apr 18;11(4):e0153692
pubmed: 27088720
Gene. 2012 Jul 25;503(2):179-93
pubmed: 22575727
Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18543-8
pubmed: 18000039
Nat Med. 2015 Jul;21(7):751-9
pubmed: 26099045
Eur Biophys J. 2017 May;46(4):309-324
pubmed: 27645213
Curr Biol. 2016 Mar 7;26(5):563-74
pubmed: 26853359
Nature. 2004 Feb 19;427(6976):695
pubmed: 14973470
Physiol Rep. 2016 Nov;4(21):
pubmed: 27905300
Nat Rev Cancer. 2009 Feb;9(2):108-22
pubmed: 19165226
Nat Protoc. 2018 May;13(5):1091-1105
pubmed: 29674756
Development. 2013 Oct;140(19):4051-9
pubmed: 24046320
Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):5586-91
pubmed: 24706777
Mol Biol Cell. 2017 Nov 7;28(23):3215-3228
pubmed: 28931601
J Cell Sci. 2015 Feb 15;128(4):781-9
pubmed: 25609711
Cell. 2000 Jan 7;100(1):57-70
pubmed: 10647931
Nat Cell Biol. 2018 Dec;20(12):1349-1360
pubmed: 30482943
Cell. 1998 Oct 30;95(3):331-41
pubmed: 9814704
Proc Natl Acad Sci U S A. 2005 Mar 1;102(9):3318-23
pubmed: 15728365
Curr Opin Cell Biol. 2018 Apr;51:15-21
pubmed: 29153702
Sci Rep. 2017 Oct 3;7(1):12568
pubmed: 28974715
Nat Commun. 2017 Dec 8;8(1):1995
pubmed: 29222471
Cell. 1998 Oct 30;95(3):319-29
pubmed: 9814703
Nat Rev Cancer. 2015 Aug;15(8):473-83
pubmed: 26156638
Nature. 2012 Apr 15;484(7395):542-5
pubmed: 22504180
Genes Dev. 2004 Aug 15;18(16):1909-25
pubmed: 15314019
Clin Exp Metastasis. 2015 Apr;32(4):369-81
pubmed: 25822899
Genes Dev. 2002 Sep 1;16(17):2286-99
pubmed: 12208851
Phys Rev Lett. 2011 Oct 28;107(18):188102
pubmed: 22107677
Development. 2018 Oct 17;145(20):
pubmed: 30254143
Science. 2012 Oct 12;338(6104):212-5
pubmed: 23066072
Curr Biol. 2016 Mar 7;26(5):670-7
pubmed: 26898471
Cell. 2004 Apr 2;117(1):107-16
pubmed: 15066286
Nat Biomed Eng. 2016;1:
pubmed: 28966873
Nature. 2012 Jan 18;481(7381):306-13
pubmed: 22258609
Am J Physiol Cell Physiol. 2000 Nov;279(5):C1345-50
pubmed: 11029281