Integrative mRNA-miRNA interaction analysis associated with the immune response of Epinephelus coioddes to Vibrio alginolyticus infection.

Animals Bass / genetics Fish Diseases / immunology Gene Expression Regulation / immunology Immunity, Innate / genetics MicroRNAs / metabolism RNA, Messenger / metabolism Vibrio Infections / immunology Vibrio alginolyticus / physiology
Epinephelus coioddes KEGG analysis The temporal expression Vibrio alginolyticus mRNA-miRNA interaction

Journal

Fish & shellfish immunology
ISSN: 1095-9947
Titre abrégé: Fish Shellfish Immunol
Pays: England
ID NLM: 9505220

Informations de publication

Date de publication:
Jul 2019
Historique:
received: 10 01 2019
revised: 29 04 2019
accepted: 04 05 2019
pubmed: 12 5 2019
medline: 21 8 2019
entrez: 12 5 2019
Statut: ppublish

Résumé

MicroRNAs (miRNAs) are a kind of small non-coding RNAs that have been reported to play a vital role in mediating host-pathogen interactions. High-throughput sequencing technology was applied to identify and illuminate mRNAs and miRNAs from grouper infected with Vibrio alginolyticus. The KEGG pathway enrichment analysis showed that the most significate DEGs are associated with Toll-like receptor signaling pathway and NOD-like receptor signaling pathway. We obtained 374 known miRNAs and 116 novel miRNAs. During them, there are 31 up-regulated miRNAs and 93 down-regulated miRNAs. miRNA-mRNA GO and KEGG analysis show that there are 90 miRNAs associated with the immune system. The target genes of immune-related miRNAs (miR-142, miR-146, miR-150, miR-155, miR-203, miR-205, miR-24, miR-31) and genes (CD80, IL-2, AMPK, PI3K) in Epinephelus coioddes were predicted and validated. This study provides an opportunity to further understanding the molecular mechanisms especially the immune system of miRNA regulation in Epinephelus coioddes host-pathogen interactions.

Identifiants

DOI: 10.1016/j.fsi.2019.05.006 PMID: 31077847
pubmed: 31077847
pii: S1050-4648(19)30562-5
doi: 10.1016/j.fsi.2019.05.006
pii:
doi:

Substances chimiques

MicroRNAs 0
RNA, Messenger 0

Types de publication

Journal Article

Langues

eng

Pagination

404-412

Informations de copyright

Copyright © 2019. Published by Elsevier Ltd.

Auteurs

Huan Kang (H)

Guangzhou Key Laboratory of Subtropical Biodiversity and Biomonitoring, Guangdong Provincial Key Laboratory for Healthy and Safe Aquaculture, Key Laboratory of Ecology and Environmental Science in Guangdong Higher Education, College of Life Science, South China Normal University, Guangzhou, 510631, PR China.

Qing-Jian Liang (QJ)

Guangzhou Key Laboratory of Subtropical Biodiversity and Biomonitoring, Guangdong Provincial Key Laboratory for Healthy and Safe Aquaculture, Key Laboratory of Ecology and Environmental Science in Guangdong Higher Education, College of Life Science, South China Normal University, Guangzhou, 510631, PR China.

Rui Hu (R)

Guangzhou Key Laboratory of Subtropical Biodiversity and Biomonitoring, Guangdong Provincial Key Laboratory for Healthy and Safe Aquaculture, Key Laboratory of Ecology and Environmental Science in Guangdong Higher Education, College of Life Science, South China Normal University, Guangzhou, 510631, PR China.

Zhong-Hua Li (ZH)

Guangzhou Key Laboratory of Subtropical Biodiversity and Biomonitoring, Guangdong Provincial Key Laboratory for Healthy and Safe Aquaculture, Key Laboratory of Ecology and Environmental Science in Guangdong Higher Education, College of Life Science, South China Normal University, Guangzhou, 510631, PR China.

Yuan Liu (Y)

Guangzhou Key Laboratory of Subtropical Biodiversity and Biomonitoring, Guangdong Provincial Key Laboratory for Healthy and Safe Aquaculture, Key Laboratory of Ecology and Environmental Science in Guangdong Higher Education, College of Life Science, South China Normal University, Guangzhou, 510631, PR China.

Wei-Na Wang (WN)

Guangzhou Key Laboratory of Subtropical Biodiversity and Biomonitoring, Guangdong Provincial Key Laboratory for Healthy and Safe Aquaculture, Key Laboratory of Ecology and Environmental Science in Guangdong Higher Education, College of Life Science, South China Normal University, Guangzhou, 510631, PR China. Electronic address: wangwn@scnu.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Integrative mRNA-miRNA interaction analysis...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Poissons › Perciformes › Serran › Integrative mRNA-miRNA interaction analysis...
questionsmedicales.fr › Maladies de l'animal › Maladies des poissons › Integrative mRNA-miRNA interaction analysis...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Integrative mRNA-miRNA interaction analysis...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité innée › Integrative mRNA-miRNA interaction analysis...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Petit ARN non traduit › microARN › Integrative mRNA-miRNA interaction analysis...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN messager › Integrative mRNA-miRNA interaction analysis...
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Infections bactériennes › Infections bactériennes à Gram négatif › Infections à Vibrio › Integrative mRNA-miRNA interaction analysis...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Vibrionaceae › Vibrio › Vibrio alginolyticus › Integrative mRNA-miRNA interaction analysis...