The role of protein SUMOylation in rheumatoid arthritis.
Post-translational modifications
Proteins
Rheumatoid arthritis
Small ubiquitin-like modifier
Journal
Journal of autoimmunity
ISSN: 1095-9157
Titre abrégé: J Autoimmun
Pays: England
ID NLM: 8812164
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
27
03
2019
revised:
02
05
2019
accepted:
04
05
2019
pubmed:
13
5
2019
medline:
23
7
2020
entrez:
13
5
2019
Statut:
ppublish
Résumé
Small ubiquitin-like modifier (SUMO) proteins, as a subgroup of post-translational modifiers, act to change the function of proteins. Through their interactions with different targets, immune pathways, and the responses they elicit, can be affected by these SUMO conjugations. Thus, both a change to protein function and involvement in immune pathways has the potential to promote an efficient immune response to either a pathogenic challenge, or the development of an imbalance that could lead to an autoimmune-based disease. Also, a variety of changes such as mutations and polymorphisms can interfere with common functions of these modifications and move an effective immune response in the direction of an autoimmune disease. The present review discusses the general characteristics of SUMO proteins and focuses on their involvement in rheumatoid arthritis as an autoimmune disease.
Identifiants
pubmed: 31078376
pii: S0896-8411(19)30197-0
doi: 10.1016/j.jaut.2019.05.006
pii:
doi:
Substances chimiques
Small Ubiquitin-Related Modifier Proteins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-7Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.