Mechanisms of Genomic Instability in Breast Cancer.

Biomarkers, Tumor Breast Neoplasms / diagnosis Chromosomal Instability DNA Damage Disease Progression Female Genetic Association Studies Genetic Predisposition to Disease Genetic Variation Genomic Instability Humans Molecular Targeted Therapy
DNA damage repair aneuploidy breast cancer chromosome instability genomic instability

Journal

Trends in molecular medicine
ISSN: 1471-499X
Titre abrégé: Trends Mol Med
Pays: England
ID NLM: 100966035

Informations de publication

Date de publication:
07 2019
Historique:
received: 05 02 2019
revised: 29 03 2019
accepted: 04 04 2019
pubmed: 13 5 2019
medline: 1 7 2020
entrez: 13 5 2019
Statut: ppublish

Résumé

Breast cancer is the most common cancer among women globally. Genomic instability (GI) refers to the increased tendency to accrue genomic alterations. It drives heterogeneity and is a hallmark of cancer. Genomic integrity is closely guarded by several mechanisms, including DNA damage checkpoints, the DNA repair machinery, and the mitotic checkpoint. Alterations in these surveillance mechanisms cause GI. In breast cancer, several pathways maintaining genomic integrity are distinctly altered, including some that have been successfully exploited for therapeutic targeting. In this review, we comprehensively discuss the recent advances on the mechanisms of GI in breast cancer, highlighting DNA repair defects and chromosome segregation errors during mitosis. We further review the clinical implications and therapeutic potential of targeting GI in the era of precision medicine.

Identifiants

DOI: 10.1016/j.molmed.2019.04.004 PMID: 31078431
pubmed: 31078431
pii: S1471-4914(19)30090-5
doi: 10.1016/j.molmed.2019.04.004
pii:
doi:

Substances chimiques

Biomarkers, Tumor 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

595-611

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

Auteurs

Pascal H G Duijf (PHG)

University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, 37 Kent Street, Brisbane, QLD, 4102, Australia.

Devathri Nanayakkara (D)

QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, QLD, 4006, Australia.

Katia Nones (K)

QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, QLD, 4006, Australia.

Sriganesh Srihari (S)

QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, QLD, 4006, Australia.

Murugan Kalimutho (M)

QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, QLD, 4006, Australia. Electronic address: Murugan.Kalimutho@qimrberghofer.edu.au.

Kum Kum Khanna (KK)

QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, QLD, 4006, Australia. Electronic address: KumKum.Khanna@qimrberghofer.edu.au.

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Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Marqueurs biologiques tumoraux › Mechanisms of Genomic Instability in Breast Cancer.
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies du sein › Tumeurs du sein › Mechanisms of Genomic Instability in Breast Cancer.
questionsmedicales.fr › Phénomènes génétiques › Instabilité du génome › Instabilité des chromosomes › Mechanisms of Genomic Instability in Breast Cancer.
questionsmedicales.fr › Phénomènes génétiques › Altération de l'ADN › Mechanisms of Genomic Instability in Breast Cancer.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Évolution de la maladie › Mechanisms of Genomic Instability in Breast Cancer.
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Études d'associations génétiques › Mechanisms of Genomic Instability in Breast Cancer.
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › Mechanisms of Genomic Instability in Breast Cancer.
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mechanisms of Genomic Instability in Breast Cancer.
questionsmedicales.fr › Phénomènes génétiques › Instabilité du génome › Mechanisms of Genomic Instability in Breast Cancer.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Mechanisms of Genomic Instability in Breast Cancer.
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Thérapie moléculaire ciblée › Mechanisms of Genomic Instability in Breast Cancer.