Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer's Disease biomarker discovery cohort.
Aged
Amyloid beta-Peptides
/ blood
Amyloidosis
/ blood
Biomarkers
/ blood
Brain
/ pathology
Cognitive Dysfunction
/ diagnosis
Cohort Studies
Female
Hippocampus
/ metabolism
Humans
Magnetic Resonance Imaging
Male
Memory
/ physiology
Metabolomics
Middle Aged
Neuropsychological Tests
tau Proteins
/ blood
Alzheimer's disease
Amyloid
Biomarkers
Brain volume measurements
CSF
Cognitive function measurements
Dementia
EMIF-AD
Metabolomics
Tau
Journal
Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
08
08
2018
revised:
06
02
2019
accepted:
04
03
2019
pubmed:
13
5
2019
medline:
23
6
2020
entrez:
13
5
2019
Statut:
ppublish
Résumé
A critical and as-yet unmet need in Alzheimer's disease (AD) is the discovery of peripheral small molecule biomarkers. Given that brain pathology precedes clinical symptom onset, we set out to test whether metabolites in blood associated with pathology as indexed by cerebrospinal fluid (CSF) AD biomarkers. This study analyzed 593 plasma samples selected from the European Medical Information Framework for Alzheimer's Disease Multimodal Biomarker Discovery study, of individuals who were cognitively healthy (n = 242), had mild cognitive impairment (n = 236), or had AD-type dementia (n = 115). Logistic regressions were carried out between plasma metabolites (n = 883) and CSF markers, magnetic resonance imaging, cognition, and clinical diagnosis. Eight metabolites were associated with amyloid β and one with t-tau in CSF, these were primary fatty acid amides (PFAMs), lipokines, and amino acids. From these, PFAMs, glutamate, and aspartate also associated with hippocampal volume and memory. PFAMs have been found increased and associated with amyloid β burden in CSF and clinical measures.
Identifiants
pubmed: 31078433
pii: S1552-5260(19)30074-3
doi: 10.1016/j.jalz.2019.03.004
pmc: PMC6849698
mid: NIHMS1053807
pii:
doi:
Substances chimiques
Amyloid beta-Peptides
0
Biomarkers
0
tau Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
817-827Subventions
Organisme : Medical Research Council
ID : MC_PC_17215
Pays : United Kingdom
Organisme : NIGMS NIH HHS
ID : R15 GM107864
Pays : United States
Informations de copyright
Crown Copyright © 2019. Published by Elsevier Inc. All rights reserved.
Références
Nat Med. 2014 Apr;20(4):415-8
pubmed: 24608097
Drug Discov Today. 2008 Jul;13(13-14):558-68
pubmed: 18598910
NPJ Aging Mech Dis. 2016 Jun 23;2:16012
pubmed: 28721267
Mol Biosyst. 2016 May 24;12(6):1831-41
pubmed: 27110897
Nat Med. 2017 May;23(5):631-637
pubmed: 28346411
Neurology. 1987 Jun;37(6):1057-61
pubmed: 3587629
J Biol Chem. 2007 Aug 3;282(31):22353-63
pubmed: 17496328
Pharmacol Biochem Behav. 2015 Apr;131:77-86
pubmed: 25641667
Nat Rev Neurol. 2011 Mar;7(3):137-52
pubmed: 21304480
Neurol Sci. 2013 Sep;34(9):1575-9
pubmed: 23354600
Neurosci Lett. 1997 Sep 26;234(1):59-62
pubmed: 9347946
Biostatistics. 2008 Jul;9(3):432-41
pubmed: 18079126
Curr Alzheimer Res. 2016;13(6):641-53
pubmed: 26825096
J Pharm Biomed Anal. 2016 Nov 30;131:175-182
pubmed: 27596829
Annu Rev Biochem. 2005;74:411-32
pubmed: 15952893
JAMA. 2017 Jun 13;317(22):2285-2287
pubmed: 28609518
Alzheimers Dement. 2016 Jul;12(7):815-22
pubmed: 26806385
Alzheimers Res Ther. 2014 Jul 03;6(4):37
pubmed: 25024750
Alzheimers Dement. 2017 Mar;13(3):285-295
pubmed: 28341066
J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Mar 15;1015-1016:50-61
pubmed: 26896572
Biosci Biotechnol Biochem. 2003 Jun;67(6):1284-91
pubmed: 12843655
Lancet. 2000 Feb 26;355(9205):755-6
pubmed: 10703833
Biochem Biophys Res Commun. 1997 Oct 20;239(2):473-9
pubmed: 9344854
Adv Exp Med Biol. 2003;527:105-12
pubmed: 15206722
Bioanalysis. 2011 May;3(10):1121-42
pubmed: 21585307
J Neurosci. 2003 Dec 3;23(35):11136-41
pubmed: 14657172
Chem Biodivers. 2007 Aug;4(8):1914-25
pubmed: 17712833
PLoS One. 2011;6(7):e21643
pubmed: 21779331
Biochim Biophys Acta. 2016 Jun;1862(6):1084-92
pubmed: 26957286
Alzheimers Dement (Amst). 2017 Sep 06;8:196-207
pubmed: 28951883
Chin Med J (Engl). 2011 May;124(9):1367-73
pubmed: 21740750
J Pharm Biomed Anal. 2014 Sep;98:321-6
pubmed: 24992214
J Mach Learn Res. 2012 Apr;13:1059-1062
pubmed: 26834510
PLoS Med. 2017 Mar 21;14(3):e1002266
pubmed: 28323825
Science. 2013 Oct 18;342(6156):373-7
pubmed: 24136970
Arch Biochem Biophys. 1996 Jun 15;330(2):430-4
pubmed: 8660675
J Alzheimers Dis. 2015;46(3):571-80
pubmed: 25835421
Lancet Neurol. 2010 Jan;9(1):119-28
pubmed: 20083042
Plant Mol Biol. 2002 Jan;48(1-2):155-71
pubmed: 11860207
Science. 1995 Jun 9;268(5216):1506-9
pubmed: 7770779
J Alzheimers Dis. 2012;31(4):751-8
pubmed: 22710910
Front Mol Neurosci. 2016 Aug 12;9:71
pubmed: 27570505
Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):4483-4488
pubmed: 29632177
Exp Gerontol. 2014 Dec;60:92-9
pubmed: 25456842
Alzheimers Res Ther. 2018 Jul 6;10(1):64
pubmed: 29980228
Alzheimers Dement. 2017 Mar;13(3):205-216
pubmed: 27697430
J Lipid Res. 2016 May;57(5):781-90
pubmed: 27016726
Contemp Clin Trials. 2013 Nov;36(2):616-23
pubmed: 23816492
Transl Psychiatry. 2011 Dec 13;1:e57
pubmed: 22832349
Sleep. 2013 Sep 01;36(9):1327-34
pubmed: 23997365
Alzheimers Dement. 2011 May;7(3):280-92
pubmed: 21514248
PLoS One. 2012;7(2):e32737
pubmed: 22393443
Neurology. 2017 May 9;88(19):1814-1821
pubmed: 28404803
Cell Metab. 2018 May 01;27(5):1111-1120.e3
pubmed: 29719226