Taking stock of the present and looking ahead: envisioning challenges in the design of future HIV prevention efficacy trials.
Journal
The lancet. HIV
ISSN: 2352-3018
Titre abrégé: Lancet HIV
Pays: Netherlands
ID NLM: 101645355
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
01
11
2018
revised:
28
02
2019
accepted:
25
03
2019
pubmed:
13
5
2019
medline:
2
6
2020
entrez:
13
5
2019
Statut:
ppublish
Résumé
Despite the recent success of antiretrovirals for HIV prevention, additional, more effective, or more acceptable biomedical interventions will ultimately be needed to end the HIV epidemic. Designing clinical trials to evaluate the efficacy of new products that reduce HIV infection risk is challenging because of the existence of highly effective interventions to prevent HIV. However, the implementation of these interventions is uneven, and the fact that multiple HIV prevention efficacy trials are currently evaluating new products means the field confronts uncertainty in the emerging standard of prevention. In this Viewpoint, we take stock of the current state of HIV prevention, and subsequently discuss the key challenges in designing future trials to evaluate the next generation of HIV prevention products. We also highlight gaps in the knowledge base that need to be addressed to advance the design of research. Future trials are tenable, even in the context of existing and effective interventions, and should involve careful statistical approaches and multidisciplinary collaborative design.
Identifiants
pubmed: 31078451
pii: S2352-3018(19)30133-X
doi: 10.1016/S2352-3018(19)30133-X
pmc: PMC6612578
mid: NIHMS1529465
pii:
doi:
Substances chimiques
Anti-HIV Agents
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e475-e482Subventions
Organisme : NIAID NIH HHS
ID : U01 AI068615
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI068615
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI068617
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI068635
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.
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