Toll-like receptor 5 agonist flagellin reduces influenza A virus replication independently of type I interferon and interleukin 22 and improves antiviral efficacy of oseltamivir.

Animals Antiviral Agents / administration & dosage Flagellin / administration & dosage Influenza A virus / drug effects Interferon Type I / deficiency Interleukins / deficiency Lung / drug effects Mice Mice, Inbred C57BL Mice, Knockout Orthomyxoviridae Infections / drug therapy Oseltamivir / administration & dosage Toll-Like Receptor 5 / agonists Virus Replication / drug effects Interleukin-22
Flagellin Influenza A virus Interleukin 22 TLR5 Type I interferon

Journal

Antiviral research
ISSN: 1872-9096
Titre abrégé: Antiviral Res
Pays: Netherlands
ID NLM: 8109699

Informations de publication

Date de publication:
08 2019
Historique:
received: 23 09 2018
revised: 31 03 2019
accepted: 06 05 2019
pubmed: 13 5 2019
medline: 13 6 2020
entrez: 13 5 2019
Statut: ppublish

Résumé

Influenza infections remain a burden on health care systems despite vaccination programs and marketed antiviral drugs. Immunomodulation through activation of innate sensors could represent innovative approaches to fight the flu. This study evaluated the ability of flagellin, agonist of Toll-like receptor 5 (TLR5), to control the replication of influenza A virus (IAV) in mice. First, we showed that systemic or intranasal administration of flagellin activated transcription of anti-viral genes in lung tissue. Prophylactic and therapeutic flagellin administration resulted in decreased levels of viral RNA and infectious virus in the lungs of H3N2 IAV-infected mice. The effect of the flagellin on viral replication was also observed in Ifnar

Identifiants

DOI: 10.1016/j.antiviral.2019.05.002 PMID: 31078648
pubmed: 31078648
pii: S0166-3542(18)30570-9
doi: 10.1016/j.antiviral.2019.05.002
pii:
doi:

Substances chimiques

Antiviral Agents 0
Interferon Type I 0
Interleukins 0
Tlr5 protein, mouse 0
Toll-Like Receptor 5 0
Flagellin 12777-81-0
Oseltamivir 20O93L6F9H

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

28-35

Informations de copyright

Copyright © 2019. Published by Elsevier B.V.

Auteurs

Anne-France Georgel (AF)

Univ. Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR8204, CIIL-Center for Infection and Immunity of Lille, Lille, France; Groupement des Hôpitaux de l'Institut Catholique de Lille, Lille, France.

Delphine Cayet (D)

Univ. Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR8204, CIIL-Center for Infection and Immunity of Lille, Lille, France.

Andrés Pizzorno (A)

Laboratoire Virologie et Pathologie Humaine - VirPath Team, Centre International de Recherche en Infectiologie (CIRI), Inserm U1111, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Université Claude Bernard Lyon 1, Université de Lyon, Lyon, France.

Manuel Rosa-Calatrava (M)

Laboratoire Virologie et Pathologie Humaine - VirPath Team, Centre International de Recherche en Infectiologie (CIRI), Inserm U1111, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Université Claude Bernard Lyon 1, Université de Lyon, Lyon, France; VirNext, Faculté de Médecine RTH Laennec, Université Claude Bernard Lyon 1, Université de Lyon, Lyon, 69008, France.

Christophe Paget (C)

Univ. Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR8204, CIIL-Center for Infection and Immunity of Lille, Lille, France; INSERM U1100, Centre d'Etude des Pathologies Respiratoires (CEPR), Université de Tours, France.

Valentin Sencio (V)

Univ. Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR8204, CIIL-Center for Infection and Immunity of Lille, Lille, France.

Jean Dubuisson (J)

Univ. Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR8204, CIIL-Center for Infection and Immunity of Lille, Lille, France.

François Trottein (F)

Univ. Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR8204, CIIL-Center for Infection and Immunity of Lille, Lille, France.

Jean-Claude Sirard (JC)

Univ. Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR8204, CIIL-Center for Infection and Immunity of Lille, Lille, France. Electronic address: jean-claude.sirard@inserm.fr.

Christophe Carnoy (C)

Univ. Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR8204, CIIL-Center for Infection and Immunity of Lille, Lille, France. Electronic address: christophe.carnoy@univ-lille.fr.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Toll-like receptor 5 agonist flagellin reduces...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiviraux › Toll-like receptor 5 agonist flagellin reduces...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › Flagelline › Toll-like receptor 5 agonist flagellin reduces...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN de polarité négative › Orthomyxoviridae › Influenzavirus A › Virus de la grippe A › Toll-like receptor 5 agonist flagellin reduces...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interférons › Interféron de type I › Toll-like receptor 5 agonist flagellin reduces...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Toll-like receptor 5 agonist flagellin reduces...
questionsmedicales.fr › Appareil respiratoire › Poumon › Toll-like receptor 5 agonist flagellin reduces...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Toll-like receptor 5 agonist flagellin reduces...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Toll-like receptor 5 agonist flagellin reduces...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Toll-like receptor 5 agonist flagellin reduces...
questionsmedicales.fr › Infection › Maladies virales › Infections à virus à ARN › Infections à Orthomyxoviridae › Toll-like receptor 5 agonist flagellin reduces...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures alicycliques › Cyclohexanes › Cyclohexènes › Oséltamivir › Toll-like receptor 5 agonist flagellin reduces...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs de reconnaissance de motifs moléculaires › Récepteurs de type Toll › Récepteur de type Toll-5 › Toll-like receptor 5 agonist flagellin reduces...
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Réplication virale › Toll-like receptor 5 agonist flagellin reduces...