Potential Diagnostic and Prognostic Role of Microenvironment in Malignant Pleural Mesothelioma.

Female Humans Lung Neoplasms / diagnosis Male Mesothelioma / diagnosis Mesothelioma, Malignant Prognosis Tumor Microenvironment
Immune checkpoints Malignant pleural mesothelioma Myeloid-derived suppressor cells T-regulatory cells Tumor-infiltrating lymphocytes

Journal

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
ISSN: 1556-1380
Titre abrégé: J Thorac Oncol
Pays: United States
ID NLM: 101274235

Informations de publication

Date de publication:
08 2019
Historique:
received: 21 11 2018
revised: 12 03 2019
accepted: 31 03 2019
pubmed: 13 5 2019
medline: 24 7 2020
entrez: 13 5 2019
Statut: ppublish

Résumé

A comprehensive analysis of the immune cell infiltrate collected from pleural fluid and from biopsy specimens of malignant pleural mesothelioma (MPM) may contribute to understanding the immune-evasion mechanisms related to tumor progression, aiding in differential diagnosis and potential prognostic stratification. Until now such approach has not routinely been verified. We enrolled 275 patients with an initial clinical diagnosis of pleural effusion. Specimens of pleural fluids and pleural biopsy samples used for the pathologic diagnosis and the immune phenotype analyses were blindly investigated by multiparametric flow cytometry. The results were analyzed using the Kruskal-Wallis test. The Kaplan-Meier and log-rank tests were used to correlate immune phenotype data with patients' outcome. The cutoffs of intratumor T-regulatory (>1.1%) cells, M2-macrophages (>36%), granulocytic and monocytic myeloid-derived suppressor cells (MDSC; >5.1% and 4.2%, respectively), CD4 molecule-positive (CD4 A clear immune signature of pleural fluids and tissues of MPM patients may contribute to better predict patients' outcome.

Identifiants

DOI: 10.1016/j.jtho.2019.03.029 PMID: 31078776
pubmed: 31078776
pii: S1556-0864(19)30357-0
doi: 10.1016/j.jtho.2019.03.029
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1458-1471

Commentaires et corrections

Type : ErratumIn

Informations de copyright

Copyright © 2019 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved.

Auteurs

Iris C Salaroglio (IC)

Department of Oncology, University of Torino, Torino, Italy.

Joanna Kopecka (J)

Department of Oncology, University of Torino, Torino, Italy.

Francesca Napoli (F)

Pathology Unit, Department of Oncology at San Luigi Hospital, University of Torino, Orbassano, Italy.

Monica Pradotto (M)

Thoracic Oncology Unit and Medical Oncology Division, Department of Oncology at San Luigi Hospital, University of Torino Regione Gonzole 10, Orbassano, Italy.

Francesca Maletta (F)

Department of Oncology, University of Torino, Torino, Italy; Pathology Unit, Department of Oncology at AOU Città della Salute e della Scienza, Torino, Italy.

Lorena Costardi (L)

Thoracic Surgery Unit, Department of Surgery, AOU Città della Salute e Della Scienza, University of Torino, Torino, Italy.

Matteo Gagliasso (M)

Thoracic Surgery Unit, Department of Oncology at San Luigi Hospital, University of Torino, Orbassano, Italy.

Vladan Milosevic (V)

Department of Oncology, University of Torino, Torino, Italy.

Preeta Ananthanarayanan (P)

Department of Oncology, University of Torino, Torino, Italy.

Paolo Bironzo (P)

Department of Oncology, University of Torino, Torino, Italy; Thoracic Oncology Unit and Medical Oncology Division, Department of Oncology at San Luigi Hospital, University of Torino Regione Gonzole 10, Orbassano, Italy.

Fabrizio Tabbò (F)

Department of Oncology, University of Torino, Torino, Italy; Thoracic Oncology Unit and Medical Oncology Division, Department of Oncology at San Luigi Hospital, University of Torino Regione Gonzole 10, Orbassano, Italy.

Carlotta F Cartia (CF)

Thoracic Surgery Unit, Department of Oncology at San Luigi Hospital, University of Torino, Orbassano, Italy.

Erika Passone (E)

Thoracic Surgery Unit, Department of Surgery, AOU Città della Salute e Della Scienza, University of Torino, Torino, Italy.

Valentina Comunanza (V)

Department of Oncology, University of Torino, Torino, Italy; Candiolo Cancer Institute - FPO IRCCS, Candiolo, Department of Oncology, University of Torino, Candiolo, Italy.

Francesco Ardissone (F)

Thoracic Surgery Unit, Department of Oncology at San Luigi Hospital, University of Torino, Orbassano, Italy.

Enrico Ruffini (E)

Thoracic Surgery Unit, Department of Surgery, AOU Città della Salute e Della Scienza, University of Torino, Torino, Italy.

Federico Bussolino (F)

Department of Oncology, University of Torino, Torino, Italy; Candiolo Cancer Institute - FPO IRCCS, Candiolo, Department of Oncology, University of Torino, Candiolo, Italy.

Luisella Righi (L)

Department of Oncology, University of Torino, Torino, Italy; Pathology Unit, Department of Oncology at San Luigi Hospital, University of Torino, Orbassano, Italy.

Silvia Novello (S)

Department of Oncology, University of Torino, Torino, Italy; Thoracic Oncology Unit and Medical Oncology Division, Department of Oncology at San Luigi Hospital, University of Torino Regione Gonzole 10, Orbassano, Italy.

Massimo Di Maio (M)

Department of Oncology, University of Torino, Torino, Italy; Medical Oncology Division, Department of Oncology at AOU Ordine Mauriziano di Torino, Torino, Italy.

Mauro Papotti (M)

Department of Oncology, University of Torino, Torino, Italy; Pathology Unit, Department of Oncology at AOU Città della Salute e della Scienza, Torino, Italy.

Giorgio V Scagliotti (GV)

Department of Oncology, University of Torino, Torino, Italy; Thoracic Oncology Unit and Medical Oncology Division, Department of Oncology at San Luigi Hospital, University of Torino Regione Gonzole 10, Orbassano, Italy.

Chiara Riganti (C)

Department of Oncology, University of Torino, Torino, Italy; Interdepartmental Center "G. Scansetti" for the Study of Asbestos and Other Toxic Particulates, University of Torino, Torino, Italy. Electronic address: chiara.riganti@unito.it.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Potential Diagnostic and Prognostic Role of...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › Potential Diagnostic and Prognostic Role of...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Tumeurs mésotheliales › Mésothéliome › Potential Diagnostic and Prognostic Role of...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs de la plèvre › Mésothéliome malin › Potential Diagnostic and Prognostic Role of...
questionsmedicales.fr › Diagnostic › Pronostic › Potential Diagnostic and Prognostic Role of...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral › Potential Diagnostic and Prognostic Role of...