Promotion of Cell Migration into a Hydrophobically modified Alaska Pollock Gelatin-Based Hydrogel.
cell migration
cell transplantation
gelatin
heterogeneous polymers
hydrogels
Journal
Macromolecular bioscience
ISSN: 1616-5195
Titre abrégé: Macromol Biosci
Pays: Germany
ID NLM: 101135941
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
13
03
2019
revised:
26
04
2019
pubmed:
14
5
2019
medline:
11
4
2020
entrez:
14
5
2019
Statut:
ppublish
Résumé
In situ chemically cross-linkable hydrogels composed of hexyl group-modified Alaska pollock-derived gelatin (C6-ApGltn) and poly(ethylene glycol)-based four-armed cross-linker is developed. Water droplets are quickly absorbed into the C6-ApGltn hydrogel in the first 10 s compared with original ApGltn (Org-ApGltn), and the final contact angle on C6-ApGltn is significantly lower than that on Org-ApGltn. Using a fluorescent probe, an increase in fluorescence intensity on C6-ApGltn compared to that on Org-ApGltn is found, indicating the formation of a hydrophobic pocket. Moreover, the promotion of cell migration into the C6-ApGltn hydrogel is observed in vitro and in vivo compared with Org-ApGltn hydrogel, despite no significant difference in elastic modulus. Therefore, the C6-ApGltn hydrogel could potentially be used as a supporting material for cell transplantation and tissue/organ engineering.
Identifiants
pubmed: 31081246
doi: 10.1002/mabi.201900083
doi:
Substances chimiques
Hydrogels
0
Water
059QF0KO0R
Gelatin
9000-70-8
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1900083Informations de copyright
© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.