Sox2 Acts in Thalamic Neurons to Control the Development of Retina-Thalamus-Cortex Connectivity.
Biological Sciences
Developmental Neuroscience
Neuroscience
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
31 May 2019
31 May 2019
Historique:
received:
04
02
2019
revised:
05
04
2019
accepted:
23
04
2019
pubmed:
15
5
2019
medline:
15
5
2019
entrez:
15
5
2019
Statut:
ppublish
Résumé
Visual system development involves the formation of neuronal projections connecting the retina to the thalamic dorso-lateral geniculate nucleus (dLGN) and the thalamus to the visual cerebral cortex. Patients carrying mutations in the SOX2 transcription factor gene present severe visual defects, thought to be linked to SOX2 functions in the retina. We show that Sox2 is strongly expressed in mouse postmitotic thalamic projection neurons. Cre-mediated deletion of Sox2 in these neurons causes reduction of the dLGN, abnormal distribution of retino-thalamic and thalamo-cortical projections, and secondary defects in cortical patterning. Reduced expression, in mutants, of Sox2 target genes encoding ephrin-A5 and the serotonin transport molecules SERT and vMAT2 (important for establishment of thalamic connectivity) likely provides a molecular contribution to these defects. These findings unveil thalamic SOX2 function as a novel regulator of visual system development and a plausible additional cause of brain-linked genetic blindness in humans.
Identifiants
pubmed: 31082736
pii: S2589-0042(19)30127-0
doi: 10.1016/j.isci.2019.04.030
pmc: PMC6517317
pii:
doi:
Types de publication
Journal Article
Langues
eng
Pagination
257-273Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.
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