A Role for NF-κB in Organ Specific Cancer and Cancer Stem Cells.
NF-κB
bone cancer
cancer stem cells
colon cancer
glioblastoma multiforme
lung cancer
multiple myeloma
ovarian cancer
pediatric cancer
prostate cancer
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
11 May 2019
11 May 2019
Historique:
received:
11
03
2019
revised:
02
05
2019
accepted:
08
05
2019
entrez:
15
5
2019
pubmed:
15
5
2019
medline:
15
5
2019
Statut:
epublish
Résumé
Cancer stem cells (CSCs) account for tumor initiation, invasiveness, metastasis, and recurrence in a broad range of human cancers. Although being a key player in cancer development and progression by stimulating proliferation and metastasis and preventing apoptosis, the role of the transcription factor NF-κB in cancer stem cells is still underestimated. In the present review, we will evaluate the role of NF-κB in CSCs of glioblastoma multiforme, ovarian cancer, multiple myeloma, lung cancer, colon cancer, prostate cancer, as well as cancer of the bone. Next to summarizing current knowledge regarding the presence and contribution of CSCs to the respective types of cancer, we will emphasize NF-κB-mediated signaling pathways directly involved in maintaining characteristics of cancer stem cells associated to tumor progression. Here, we will also focus on the status of NF-κB-activity predominantly in CSC populations and the tumor mass. Genetic alterations leading to NF-κB activity in glioblastoma, ependymoma, and multiple myeloma will be discussed.
Identifiants
pubmed: 31083587
pii: cancers11050655
doi: 10.3390/cancers11050655
pmc: PMC6563002
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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