Detection of Increased Vascular Signal in Arthritis-Prone Rats Without Joint Swelling Using Superb Microvascular Imaging Ultrasonography.

Animals Ankle Joint / blood supply Arthritis, Rheumatoid / diagnostic imaging Disease Models, Animal Rats Severity of Illness Index Synovial Membrane / diagnostic imaging Ultrasonography / methods
Animal model Power Doppler Rheumatoid arthritis Superb microvascular imaging Synovitis Ultrasound

Journal

Ultrasound in medicine & biology
ISSN: 1879-291X
Titre abrégé: Ultrasound Med Biol
Pays: England
ID NLM: 0410553

Informations de publication

Date de publication:
08 2019
Historique:
received: 04 01 2019
revised: 10 03 2019
accepted: 01 04 2019
pubmed: 16 5 2019
medline: 2 4 2020
entrez: 16 5 2019
Statut: ppublish

Résumé

This study aimed to determine whether ultrasonography (US) can detect increased vascular signal in the synovial tissue before overt synovitis in rheumatoid arthritis (RA). Env-pX rats that spontaneously develop RA-like synovitis were used. Ankle joints of 15 pre-morbid env-pX rats were observed with power Doppler and superb microvascular imaging (SMI) using an ultrahigh-frequency (8-24 MHz) probe. Signal values were counted as the number of pixels. The total number of vessels and vessel area in the synovial tissue were histologically evaluated. Dilated vessels were determined from the mean value of synovial vessels in three wild-type rats. In all env-pX rats, apparent synovial proliferation was not observed. However, vasodilation was evident. Only SMI values were significantly correlated with the number of dilated vessels (r = 0.585, p = 0.022) but not with the total number of vessels. US with SMI using ultrahigh-frequency probe can detect increased vascular signal in the synovial tissue of arthritis-prone rats.

Identifiants

DOI: 10.1016/j.ultrasmedbio.2019.04.002 PMID: 31085028
pubmed: 31085028
pii: S0301-5629(19)30139-5
doi: 10.1016/j.ultrasmedbio.2019.04.002
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

2086-2093

Informations de copyright

Copyright © 2019 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.

Auteurs

Tatsunori Horie (T)

Diagnostic Center for Sonography, Hokkaido University Hospital, Kita-ku, Sapporo, Japan; Department of Radiological Technology, Hokkaido University Hospital, Kita-ku, Sapporo, Japan.

Mutsumi Nishida (M)

Diagnostic Center for Sonography, Hokkaido University Hospital, Kita-ku, Sapporo, Japan; Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital, Kita-ku, Sapporo, Japan.

Shun Tanimura (S)

Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita-ku, Sapporo, Japan.

Tamotsu Kamishima (T)

Department of Biomedical Science and Engineering, Faculty of Health Sciences, Hokkaido University, Kita-ku, Sapporo, Japan.

Erika Tamai (E)

Department of Biomedical Science and Engineering, Faculty of Health Sciences, Hokkaido University, Kita-ku, Sapporo, Japan.

Yutaka Morimura (Y)

Department of Medical Laboratory Science, Faculty of Health Sciences, Hokkaido University, Kita-ku, Sapporo, Japan.

Yuka Nishibata (Y)

Department of Medical Laboratory Science, Faculty of Health Sciences, Hokkaido University, Kita-ku, Sapporo, Japan.

Sakiko Masuda (S)

Department of Medical Laboratory Science, Faculty of Health Sciences, Hokkaido University, Kita-ku, Sapporo, Japan.

Daigo Nakazawa (D)

Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita-ku, Sapporo, Japan.

Utano Tomaru (U)

Department of Pathology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita-ku, Sapporo, Japan.

Tatsuya Atsumi (T)

Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita-ku, Sapporo, Japan.

Akihiro Ishizu (A)

Department of Medical Laboratory Science, Faculty of Health Sciences, Hokkaido University, Kita-ku, Sapporo, Japan. Electronic address: aishizu@med.hokudai.ac.jp.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Detection of Increased Vascular Signal in...
questionsmedicales.fr › Appareil locomoteur › Squelette › Articulations › Articulations du pied › Articulation talocrurale › Detection of Increased Vascular Signal in...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Polyarthrite rhumatoïde › Detection of Increased Vascular Signal in...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Detection of Increased Vascular Signal in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Detection of Increased Vascular Signal in...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Enquêtes et questionnaires › Enquêtes de santé › Indicateurs d'état de santé › Acuité des besoins du patient › Indice de gravité de la maladie › Detection of Increased Vascular Signal in...
questionsmedicales.fr › Appareil locomoteur › Squelette › Articulations › Capsule articulaire › Membrane synoviale › Detection of Increased Vascular Signal in...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Échographie › Detection of Increased Vascular Signal in...