Optimization of miRNA delivery by using a polymeric conjugate based on deoxycholic acid-modified polyethylenimine.
Cells, Cultured
Deoxycholic Acid
/ administration & dosage
Ephrin-A3
/ genetics
Gene Silencing
Human Umbilical Vein Endothelial Cells
/ metabolism
Humans
MicroRNAs
/ administration & dosage
Polyethyleneimine
/ administration & dosage
Protein Tyrosine Phosphatase, Non-Receptor Type 1
/ genetics
Transfection
Wound Healing
Deoxycholic acid
Gene delivery
Gene silencing
MicroRNA
Polyethylenimine
Journal
International journal of pharmaceutics
ISSN: 1873-3476
Titre abrégé: Int J Pharm
Pays: Netherlands
ID NLM: 7804127
Informations de publication
Date de publication:
30 Jun 2019
30 Jun 2019
Historique:
received:
16
02
2019
revised:
01
05
2019
accepted:
05
05
2019
pubmed:
16
5
2019
medline:
18
12
2019
entrez:
16
5
2019
Statut:
ppublish
Résumé
Safe and efficient delivery of microRNA (miRNA) molecules is essential for their successful transition from research to the clinic setting. In the present study, we have used a bile acid, deoxycholic acid (DA), to modify 1.8 kDa branched polyethylenimine (bPEI
Identifiants
pubmed: 31085260
pii: S0378-5173(19)30362-X
doi: 10.1016/j.ijpharm.2019.05.009
pii:
doi:
Substances chimiques
Ephrin-A3
0
MIRN210 microRNA, human
0
MicroRNAs
0
Deoxycholic Acid
005990WHZZ
Polyethyleneimine
9002-98-6
PTPN1 protein, human
EC 3.1.3.48
Protein Tyrosine Phosphatase, Non-Receptor Type 1
EC 3.1.3.48
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
391-408Informations de copyright
Copyright © 2019. Published by Elsevier B.V.