Effects of chronic inhibition of Testosterone metabolism on cardiac remodeling after ischemia/reperfusion-induced myocardial damage in gonadectomized rats.
17β-estradiol
Cardiac remodeling
Cardio-protection
Metalloproteinase
Testosterone
Journal
Biology open
ISSN: 2046-6390
Titre abrégé: Biol Open
Pays: England
ID NLM: 101578018
Informations de publication
Date de publication:
13 May 2019
13 May 2019
Historique:
entrez:
16
5
2019
pubmed:
16
5
2019
medline:
16
5
2019
Statut:
epublish
Résumé
The effects of testosterone on cardiovascular homeostasis are still not well understood. The objective of this work was to evaluate the effects of testosterone in the absence or presence of inhibition of Aromatase (4-hydroxyandrostenedione) and/or 5α reductase (Finasteride) enzymatic activities on the myocardial remodeling 30 days after ischemia/reperfusion (I/R) injury in gonadectomized rats. Results showed that testosterone administration to ORX rats resulted in decreased myocardial damaged area, inflammatory infiltrates and reduced MMP-3 and 13 expressions. Interestingly, Finasteride administration resulted in a greater decrease in scar tissue, inflammatory infiltrates, along with a significant decrease in MMP-3 and 13 expressions. In contrast, 4-hydroxyandrostenedione administrations increased all parameters. Our results suggest that testosterone does not have a direct effect since simultaneous inhibition of aromatase and 5α-reductase did not induce significant changes in I/R induced myocardial injury.
Identifiants
pubmed: 31085546
pii: bio.041905
doi: 10.1242/bio.041905
pmc: PMC6550079
pii:
doi:
Types de publication
Journal Article
Langues
eng
Informations de copyright
© 2019. Published by The Company of Biologists Ltd.
Déclaration de conflit d'intérêts
Competing interestsDr Ceballos is a stockholder of Cardero Therapeutics, Inc., all rest of the authors state that they do not have any financial or other relationships that might lead to a conflict of interest.
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