SSB1/SSB2 Proteins Safeguard B Cell Development by Protecting the Genomes of B Cell Precursors.
Animals
Apoptosis
B-Lymphocytes
/ physiology
Cell Differentiation
Cells, Cultured
DNA Damage
DNA Repair
DNA-Binding Proteins
/ genetics
Genome
/ genetics
Lymphocyte Activation
Mice
Mice, Inbred C57BL
Mice, Knockout
Mutation
/ genetics
Precursor Cells, B-Lymphoid
/ physiology
Proto-Oncogene Proteins c-bcl-2
/ metabolism
Suppressor of Cytokine Signaling Proteins
/ genetics
Journal
Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R
Informations de publication
Date de publication:
15 06 2019
15 06 2019
Historique:
received:
11
12
2018
accepted:
12
04
2019
pubmed:
16
5
2019
medline:
7
3
2020
entrez:
16
5
2019
Statut:
ppublish
Résumé
Induction of programmed DNA damage and its recognition and repair are fundamental for B cell development. The ssDNA-binding protein SSB1 has been described in human cells as essential for the recognition and repair of DNA damage. To study its relevance for B cells, we recently developed
Identifiants
pubmed: 31085591
pii: jimmunol.1801618
doi: 10.4049/jimmunol.1801618
pmc: PMC6545462
doi:
Substances chimiques
DNA-Binding Proteins
0
Proto-Oncogene Proteins c-bcl-2
0
SSB-1 protein, mouse
0
SSB-2 protein, mouse
0
Suppressor of Cytokine Signaling Proteins
0
Bcl2 protein, mouse
114100-40-2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3423-3433Subventions
Organisme : Blood Cancer UK
ID : 13016
Pays : United Kingdom
Organisme : Department of Health
ID : NIHR-RP-011-053
Pays : United Kingdom
Informations de copyright
Copyright © 2019 The Authors.
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