CHD4 is essential for transcriptional repression and lineage progression in B lymphopoiesis.

Animals B-Lymphocytes / cytology Cell Lineage / genetics Chromatin Assembly and Disassembly / genetics DNA Helicases / genetics Gene Expression Regulation / genetics Lymphopoiesis / genetics Mice Mice, Transgenic Transcription, Genetic / genetics
B lymphocyte development B lymphopoiesis chromatin remodeling complexes transcriptional programming transcriptional repression

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
28 05 2019
Historique:
pubmed: 16 5 2019
medline: 9 4 2020
entrez: 16 5 2019
Statut: ppublish

Résumé

Cell lineage specification is a tightly regulated process that is dependent on appropriate expression of lineage and developmental stage-specific transcriptional programs. Here, we show that Chromodomain Helicase DNA-binding protein 4 (CHD4), a major ATPase/helicase subunit of Nucleosome Remodeling and Deacetylase Complexes (NuRD) in lymphocytes, is essential for specification of the early B cell lineage transcriptional program. In the absence of CHD4 in B cell progenitors in vivo, development of these cells is arrested at an early pro-B-like stage that is unresponsive to IL-7 receptor signaling and unable to efficiently complete V(D)J rearrangements at

Identifiants

DOI: 10.1073/pnas.1821301116 PMID: 31085655 PMC: PMC6561196
pubmed: 31085655
pii: 1821301116
doi: 10.1073/pnas.1821301116
pmc: PMC6561196
doi:

Substances chimiques

Mi-2beta protein, mouse EC 3.6.1.3
DNA Helicases EC 3.6.4.-

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

10927-10936

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI109599
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI081878
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI107343
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI115696
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI098417
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL127461
Pays : United States
Organisme : NIGMS NIH HHS
ID : F32 GM106631
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI074491
Pays : United States

Informations de copyright

Copyright © 2019 the Author(s). Published by PNAS.

Déclaration de conflit d'intérêts

The authors declare no conflict of interest.

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Auteurs

Tessa Arends (T)

Program in Molecular Biology, University of Colorado Denver, Aurora, CO 80045.

Carissa Dege (C)

Department of Immunology and Microbiology, University of Colorado Denver, Aurora, CO 80045.

Alexandra Bortnick (A)

Section of Molecular Biology, University of California, San Diego, La Jolla, CA 92093.

Thomas Danhorn (T)

Center for Genes, Environment, and Health, National Jewish Health, Denver, CO 80206.
ORCID: 0000-0002-3861-8602

Jennifer R Knapp (JR)

Center for Genes, Environment, and Health, National Jewish Health, Denver, CO 80206.

Haiqun Jia (H)

Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037.

Laura Harmacek (L)

Center for Genes, Environment, and Health, National Jewish Health, Denver, CO 80206.

Courtney J Fleenor (CJ)

Department of Biomedical Research, National Jewish Health, Denver, CO 80206.

Desiree Straign (D)

Department of Biomedical Research, National Jewish Health, Denver, CO 80206.

Kendra Walton (K)

Center for Genes, Environment, and Health, National Jewish Health, Denver, CO 80206.

Sonia M Leach (SM)

Center for Genes, Environment, and Health, National Jewish Health, Denver, CO 80206.
Department of Biomedical Research, National Jewish Health, Denver, CO 80206.

Ann J Feeney (AJ)

Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037.

Cornelis Murre (C)

Section of Molecular Biology, University of California, San Diego, La Jolla, CA 92093.

Brian P O'Connor (BP)

Department of Immunology and Microbiology, University of Colorado Denver, Aurora, CO 80045.
Center for Genes, Environment, and Health, National Jewish Health, Denver, CO 80206.
Department of Biomedical Research, National Jewish Health, Denver, CO 80206.

James R Hagman (JR)

Program in Molecular Biology, University of Colorado Denver, Aurora, CO 80045; hagmanj@njhealth.org.
Department of Immunology and Microbiology, University of Colorado Denver, Aurora, CO 80045.
Department of Biomedical Research, National Jewish Health, Denver, CO 80206.
ORCID: 0000-0002-5436-8455

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › CHD4 is essential for transcriptional...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes B › CHD4 is essential for transcriptional...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Développement embryonnaire et foetal › Développement embryonnaire › Lignage cellulaire › CHD4 is essential for transcriptional...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Assemblage et désassemblage de la chromatine › CHD4 is essential for transcriptional...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Isomerases › Helicase › CHD4 is essential for transcriptional...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › CHD4 is essential for transcriptional...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiogiques du sang › Hématopoïèse › Leucopoïèse › Lymphopoïèse › CHD4 is essential for transcriptional...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › CHD4 is essential for transcriptional...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › CHD4 is essential for transcriptional...
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › Transcription génétique › CHD4 is essential for transcriptional...