Bypassing Osmotic Shock Dilemma in a Polystyrene Resin Using the Green Solvent Cyclopentyl methyl Ether (CPME): A Morphological Perspective.
green solvent
osmotic shock
solid-phase peptide synthesis
Journal
Polymers
ISSN: 2073-4360
Titre abrégé: Polymers (Basel)
Pays: Switzerland
ID NLM: 101545357
Informations de publication
Date de publication:
13 May 2019
13 May 2019
Historique:
received:
13
04
2019
revised:
02
05
2019
accepted:
11
05
2019
entrez:
16
5
2019
pubmed:
16
5
2019
medline:
16
5
2019
Statut:
epublish
Résumé
The "osmotic shock" phenomenon is the main thing that is responsible for morphological structure alteration, which can jeopardize the use of a polymer in a chemical process. This is extremely important in solid-phase peptide synthesis (SPPS), which is the method of choice for the preparation of these important biologically active compounds. Herein, we have used Hildebrand solubility parameters (δ) to investigate the influence of different ethers that are used in the precipitation step of the SPPS using a polystyrene resin. The green cyclopentyl methyl ether (CPME) has shown to be slightly superior to 2-methyltetrahydrofurane, which is also a green ether and clearly better than the hazardous diethyl ether and
Identifiants
pubmed: 31086118
pii: polym11050874
doi: 10.3390/polym11050874
pmc: PMC6571811
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : King Saud University
ID : ISPP# 0061
Organisme : National Research Foundation
ID : Blue Sky's Research Programme # 110960
Organisme : Ministry of Science Research and Technology
ID : CTQ2015-67870-P
Organisme : Generalitat de Catalunya
ID : 2017 SGR 1439
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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