Finger-mounted quantitative micro-elastography.
Journal
Biomedical optics express
ISSN: 2156-7085
Titre abrégé: Biomed Opt Express
Pays: United States
ID NLM: 101540630
Informations de publication
Date de publication:
01 Apr 2019
01 Apr 2019
Historique:
received:
14
11
2018
revised:
17
01
2019
accepted:
05
02
2019
entrez:
16
5
2019
pubmed:
16
5
2019
medline:
16
5
2019
Statut:
epublish
Résumé
We present a finger-mounted quantitative micro-elastography (QME) probe, capable of measuring the elasticity of biological tissue in a format that avails of the dexterity of the human finger. Finger-mounted QME represents the first demonstration of a wearable elastography probe. The approach realizes optical coherence tomography-based elastography by focusing the optical beam into the sample via a single-mode fiber that is fused to a length of graded-index fiber. The fiber is rigidly affixed to a 3D-printed thimble that is mounted on the finger. Analogous to manual palpation, the probe compresses the tissue through the force exerted by the finger. The resulting deformation is measured using optical coherence tomography. Elasticity is estimated as the ratio of local stress at the sample surface, measured using a compliant layer, to the local strain in the sample. We describe the probe fabrication method and the signal processing developed to achieve accurate elasticity measurements in the presence of motion artifact. We demonstrate the probe's performance in motion-mode scans performed on homogeneous, bi-layer and inclusion phantoms and its ability to measure a thermally-induced increase in elasticity in
Identifiants
pubmed: 31086702
doi: 10.1364/BOE.10.001760
pii: 351772
pmc: PMC6484987
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1760-1773Déclaration de conflit d'intérêts
BFK: OncoRes Medical (F, I) and AC, LC: OncoRes Medical (I). The other authors declare that there are no conflicts of interest related to this article.
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