Post-genomic approach based discovery of alkylresorcinols from a cricket-associated fungus, Penicillium soppi.

Drug Discovery Enzyme Inhibitors / chemistry Molecular Structure Penicillium / chemistry Polyketide Synthases / antagonists & inhibitors Resorcinols / chemistry

Journal

Organic & biomolecular chemistry
ISSN: 1477-0539
Titre abrégé: Org Biomol Chem
Pays: England
ID NLM: 101154995

Informations de publication

Date de publication:
29 05 2019
Historique:
pubmed: 16 5 2019
medline: 21 12 2019
entrez: 16 5 2019
Statut: ppublish

Résumé

Polyketide synthase (PKS) gene-guided genome mining in a cricket-associated fungus, Penicillium soppi, revealed a cryptic biosynthetic gene cluster that contained a highly reducing PKS (HR-PKS), a type III PKS, and a P450 gene. Heterologous expression of the cluster in Aspergillus oryzae led to the isolation of novel alkylresorcinols with a unique Z,E,Z-triene motif. This study displays an unusual biosynthetic mechanism of an HR-PKS and a new releasing mechanism via a type III PKS in fungi.

Identifiants

DOI: 10.1039/c9ob00807a PMID: 31086874
pubmed: 31086874
doi: 10.1039/c9ob00807a
doi:

Substances chimiques

Enzyme Inhibitors 0
Resorcinols 0
Polyketide Synthases 79956-01-7

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

5239-5243

Auteurs

Akiho Kaneko (A)

Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 komaba, meguro-ku, Tokyo 153-8902, Japan. tasai@bio.c.u-tokyo.ac.jp.

Yohei Morishita (Y)

Kento Tsukada (K)

Tohru Taniguchi (T)

Teigo Asai (T)

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Classifications MeSH

questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Découverte de médicament › Post-genomic approach based discovery of...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Post-genomic approach based discovery of...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Post-genomic approach based discovery of...
questionsmedicales.fr › Eucaryotes › Champignons › Deuteromycota › Penicillium › Post-genomic approach based discovery of...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Complexes multienzymatiques › Polyketide synthases › Post-genomic approach based discovery of...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénols › Résorcinol › Post-genomic approach based discovery of...