Dissemination of a novel organ perfusion technique: ex vivo normothermic perfusion of deceased donor kidneys.
ex vivo
kidney
normothermic
perfusion
transplant
Journal
Artificial organs
ISSN: 1525-1594
Titre abrégé: Artif Organs
Pays: United States
ID NLM: 7802778
Informations de publication
Date de publication:
Nov 2019
Nov 2019
Historique:
received:
19
01
2019
revised:
07
04
2019
accepted:
07
05
2019
pubmed:
16
5
2019
medline:
31
3
2020
entrez:
16
5
2019
Statut:
ppublish
Résumé
Ex vivo normothermic perfusion (EVNP) technology is a promising means of organ preservation, assessment, and preconditioning prior to kidney transplantation, which has been pioneered by a single group. We describe the challenges of setting up clinical EVNP programs in 2 new centers, as well as early patient outcomes. Governance, training, and logistical pathways are described. In order to demonstrate safety and proficiency in this new technique, early patient outcomes are also described. Patient outcomes included the incidence of primary nonfunction, delayed graft function, graft and patient survival at 1 year. Contralateral kidneys undergoing static cold storage alone were used as a comparator group. Between March 2016 and July 2017, EVNP was performed on 14 kidneys from 12 donors (11 kidneys in center 1, 3 kidneys in center 2). Of the 14 kidneys that underwent EVNP, 12 organs were implanted into 10 recipients. Two pairs of kidneys were implanted as dual grafts and 1 kidney was implanted simultaneously with a pancreas. The remaining 7 kidneys were transplanted as single allografts. Seven pairs of kidneys were available for paired analysis comparing EVNP versus static cold storage. Graft and patient outcomes were comparable between the 2 preservation techniques. The introduction of a clinical EVNP service requires a careful multimodal approach, drawing on the expertise of specialists in transplantation, hematology, and microbiology. Both new clinical EVNP programs demonstrated proficiency and safety when a structured dissemination process was followed.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
E308-E319Subventions
Organisme : Rosetrees Trust and The Stoneygate Trust
ID : M727
Organisme : Royal College of Surgeons of England Research Fellowship
Organisme : National Institute for Health Research Blood and Transplant Research Unit (NIHR BTRU) in Organ Donation and Transplantation and in partnership with NHS Blood and Transplant (NHSBT).
Organisme : Guy's and St Thomas' Charity, the MRC Centre for Transplantation, and Guy's and St Thomas' NHS Foundation Trust
ID : 13101
Organisme : Northern Counties Kidney Research Fund
Organisme : Kidney Research UK
ID : SP/MEKC/1/2014
Informations de copyright
© 2019 International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc.
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