Prognostic impact of tumor growth velocity in head and neck squamous cell carcinoma treated by radiotherapy: A pilot study.
oropharynx carcinomas
progression
tumor growth
Journal
Head & neck
ISSN: 1097-0347
Titre abrégé: Head Neck
Pays: United States
ID NLM: 8902541
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
10
07
2018
revised:
10
02
2019
accepted:
16
04
2019
pubmed:
16
5
2019
medline:
27
11
2020
entrez:
16
5
2019
Statut:
ppublish
Résumé
When a patient is seen with a newly diagnosed oropharyngeal squamous cell carcinoma, it remains unclear to the treating physicians how fast the tumor growth rate is. From patients with oropharynx squamous cell carcinoma treated by radiotherapy, the investigators selected comparable diagnostic CT-scan (DiCT) and radiotherapy planning CT-scan (RtCT). Tumor and pathological lymph node volumes were measured in order to calculate tumor progression. From the selection of 19 patients, the mean absolute tumor progression rate was 0.23 ± 0.2 cm Tumor progression can be assessed based on DiCT and RtCT. Treatment delay should be avoided at all cost. Different growth patterns were evidenced. For the fast-growing tumors subgroup, pejorative clinical outcomes were suggested. Prospective studies are needed to confirm a link between fast-growing tumors and higher risk for recurrence.
Sections du résumé
BACKGROUND
When a patient is seen with a newly diagnosed oropharyngeal squamous cell carcinoma, it remains unclear to the treating physicians how fast the tumor growth rate is.
METHODS
From patients with oropharynx squamous cell carcinoma treated by radiotherapy, the investigators selected comparable diagnostic CT-scan (DiCT) and radiotherapy planning CT-scan (RtCT). Tumor and pathological lymph node volumes were measured in order to calculate tumor progression.
RESULTS
From the selection of 19 patients, the mean absolute tumor progression rate was 0.23 ± 0.2 cm
CONCLUSIONS
Tumor progression can be assessed based on DiCT and RtCT. Treatment delay should be avoided at all cost. Different growth patterns were evidenced. For the fast-growing tumors subgroup, pejorative clinical outcomes were suggested. Prospective studies are needed to confirm a link between fast-growing tumors and higher risk for recurrence.
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3041-3048Subventions
Organisme : Cliniques Universitaires Saint-Luc
ID : Grant from Fondation Saint-Luc to S. Van der Vorst
Pays : International
Informations de copyright
© 2019 Wiley Periodicals, Inc.