Hydrolyzable Tannins Are Iron Chelators That Inhibit DNA Repair Enzyme ALKBH2.
Journal
Chemical research in toxicology
ISSN: 1520-5010
Titre abrégé: Chem Res Toxicol
Pays: United States
ID NLM: 8807448
Informations de publication
Date de publication:
17 06 2019
17 06 2019
Historique:
pubmed:
16
5
2019
medline:
14
4
2020
entrez:
16
5
2019
Statut:
ppublish
Résumé
Hydrolyzable tannins are a class of polyphenolic compounds commonly found in natural products. In this work, we studied the in vitro inhibitory mechanism of six molecules in this class on ALKBH2, an Fe(II)/α-ketoglutarate-dependent DNA repair enzyme in the AlkB family. We determined the IC
Identifiants
pubmed: 31088072
doi: 10.1021/acs.chemrestox.8b00398
pmc: PMC6890495
mid: NIHMS1059983
doi:
Substances chimiques
Enzyme Inhibitors
0
Hydrolyzable Tannins
0
Iron Chelating Agents
0
ALKBH2 protein, human
EC 1.14.11.33
AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase
EC 1.14.11.33
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1082-1086Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM103430
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES028865
Pays : United States
Organisme : NCI NIH HHS
ID : R15 CA213042
Pays : United States
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