Is Cerebrospinal Fluid Superoxide Dismutase 1 a Biomarker of Tau But Not Amyloid-Induced Neurodegeneration in Alzheimer's Disease?
Aged
Aged, 80 and over
Alzheimer Disease
/ diagnosis
Amyloid
/ metabolism
Amyloid beta-Peptides
/ metabolism
Apolipoproteins E
/ genetics
Biomarkers
Cognition
Disease Susceptibility
Female
Fluorodeoxyglucose F18
/ metabolism
Humans
Magnetic Resonance Imaging
Male
Memory
Neurodegenerative Diseases
/ etiology
Positron-Emission Tomography
Superoxide Dismutase-1
/ cerebrospinal fluid
tau Proteins
/ metabolism
biomarkers
free radicals
neurodegeneration
nutrition
Journal
Antioxidants & redox signaling
ISSN: 1557-7716
Titre abrégé: Antioxid Redox Signal
Pays: United States
ID NLM: 100888899
Informations de publication
Date de publication:
10 09 2019
10 09 2019
Historique:
pubmed:
16
5
2019
medline:
24
7
2020
entrez:
16
5
2019
Statut:
ppublish
Résumé
Copper/zinc superoxide dismutase 1 (SOD1) scavenges free radicals that may otherwise damage brain parenchyma. Impaired SOD1 activity drives Alzheimer's disease (AD) neuropathology in animal models and postmortem AD brains. Yet, it is unknown how cerebrospinal fluid (CSF) SOD1 is related
Identifiants
pubmed: 31088292
doi: 10.1089/ars.2019.7762
pmc: PMC6657291
doi:
Substances chimiques
Amyloid
0
Amyloid beta-Peptides
0
Apolipoproteins E
0
Biomarkers
0
tau Proteins
0
Fluorodeoxyglucose F18
0Z5B2CJX4D
Superoxide Dismutase-1
EC 1.15.1.1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
572-578Subventions
Organisme : NIA NIH HHS
ID : R00 AG047282
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG024904
Pays : United States
Organisme : NIA NIH HHS
ID : U19 AG024904
Pays : United States
Références
Nat Neurosci. 1999 Feb;2(2):157-61
pubmed: 10195200
J Neurosci. 2006 Apr 12;26(15):3933-41
pubmed: 16611809
Neurobiol Dis. 2007 May;26(2):342-52
pubmed: 17344052
J Neurosci Res. 2008 Nov 15;86(15):3275-84
pubmed: 18646206
J Biol Chem. 2011 Dec 30;286(52):44557-68
pubmed: 22072713
JAMA Neurol. 2013 Feb;70(2):201-7
pubmed: 23147550
Acta Physiol (Oxf). 2015 Jul;214(3):329-48
pubmed: 25912260
JAMA Neurol. 2015 Sep;72(9):1013-20
pubmed: 26214150
Neurosci Lett. 1988 Oct 17;92(3):247-53
pubmed: 3200483