Counterattacking the tick bite: towards a rational design of anti-tick vaccines targeting pathogen transmission.
Animals
Arthropod Proteins
/ immunology
Borrelia
Disease Vectors
Encephalitis Viruses, Tick-Borne
Encephalitis, Tick-Borne
/ prevention & control
Female
Humans
Ixodes
/ microbiology
Lyme Disease
/ prevention & control
Male
Saliva
Tick Bites
/ prevention & control
Tick-Borne Diseases
/ prevention & control
Vaccines
/ immunology
Anaplasma
Babesia
Borrelia
Ixodes
Midgut
Rickettsia
Saliva
TBEV
Tick
Vaccine
Journal
Parasites & vectors
ISSN: 1756-3305
Titre abrégé: Parasit Vectors
Pays: England
ID NLM: 101462774
Informations de publication
Date de publication:
14 May 2019
14 May 2019
Historique:
received:
03
01
2019
accepted:
29
04
2019
entrez:
16
5
2019
pubmed:
16
5
2019
medline:
25
6
2019
Statut:
epublish
Résumé
Hematophagous arthropods are responsible for the transmission of a variety of pathogens that cause disease in humans and animals. Ticks of the Ixodes ricinus complex are vectors for some of the most frequently occurring human tick-borne diseases, particularly Lyme borreliosis and tick-borne encephalitis virus (TBEV). The search for vaccines against these diseases is ongoing. Efforts during the last few decades have primarily focused on understanding the biology of the transmitted viruses, bacteria and protozoans, with the goal of identifying targets for intervention. Successful vaccines have been developed against TBEV and Lyme borreliosis, although the latter is no longer available for humans. More recently, the focus of intervention has shifted back to where it was initially being studied which is the vector. State of the art technologies are being used for the identification of potential vaccine candidates for anti-tick vaccines that could be used either in humans or animals. The study of the interrelationship between ticks and the pathogens they transmit, including mechanisms of acquisition, persistence and transmission have come to the fore, as this knowledge may lead to the identification of critical elements of the pathogens' life-cycle that could be targeted by vaccines. Here, we review the status of our current knowledge on the triangular relationships between ticks, the pathogens they carry and the mammalian hosts, as well as methods that are being used to identify anti-tick vaccine candidates that can prevent the transmission of tick-borne pathogens.
Identifiants
pubmed: 31088506
doi: 10.1186/s13071-019-3468-x
pii: 10.1186/s13071-019-3468-x
pmc: PMC6518728
doi:
Substances chimiques
Arthropod Proteins
0
Vaccines
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
229Subventions
Organisme : FP7 Health
ID : 602272-2
Organisme : Grantová Agentura České Republiky
ID : 17-21244S
Organisme : Grantová Agentura České Republiky
ID : 17-27386S
Organisme : Grantová Agentura České Republiky
ID : 17-27393S
Organisme : Slovenská Akadémia Vied
ID : 2/0191/17
Organisme : ZonMW
ID : 522003007
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