Reduction of Some Atherogenic Indices in Patients with Non-Alcoholic Fatty Liver by Vitamin D and Calcium Co-Supplementation: A Double Blind Randomized Controlled Clinical Trial.

Atherogenic indices Calcium Non-alcoholic fatty liver Supplementation Vitamin D

Journal

Iranian journal of pharmaceutical research : IJPR
ISSN: 1735-0328
Titre abrégé: Iran J Pharm Res
Pays: Netherlands
ID NLM: 101208407

Informations de publication

Date de publication:
2019
Historique:
entrez: 16 5 2019
pubmed: 16 5 2019
medline: 16 5 2019
Statut: ppublish

Résumé

The role of non-alcoholic fatty liver disease (NAFLD) as a potential independent cardiovascular disease (CVD) risk factor has recently gained considerable attention because CVD is the common cause of death in NAFLD patients. We aimed to estimate the effects of vitamin D supplementation alone or in combination with calcium on atherogenic indices, liver function tests, and grade of disease in patients with NAFLD. One-hundred twenty NAFLD patients were randomized in a double-blind, placebo-controlled clinical trial as follows: D (1000 IU vitamin D), CaD (500 mg as calcium carbonate plus 1000 IU vitamin D) or P (placebo), once daily with meals over 12 weeks. Adjusted for all the baseline measures, reduction in serum ALT, AST, LDL-C/HDL-C, TC/HDL-C, and non-HDL-C were significantly higher in the CaD compared with the P group (

Identifiants

pubmed: 31089384
pmc: PMC6487410

Types de publication

Journal Article

Langues

eng

Pagination

496-505

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Auteurs

Farzad Shidfar (F)

Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
Colorectal Research Center, Iran University of Medical Sciences, Tehran, Iran.

Seyedeh Neda Mousavi (SN)

Department of Nutrition, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.

Hamid Lorvand Amiri (H)

Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.

Shahram Agah (S)

Colorectal Research Center, Iran University of Medical Sciences, Tehran, Iran.

Sharieh Hoseini (S)

Department of Applied chemistry, Faculty of Pharmaceutical Chemistry, Pharmaceutical Sciences Branch, Isalmic Azad University, Tehran, Iran.

Seyed Javad Hajimiresmail (SJ)

Department of Cardiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Classifications MeSH