Glycated Serum Protein Genetics and Pleiotropy with Cardiometabolic Risk Factors.
Adolescent
Adult
Aged
Aged, 80 and over
Biomarkers
/ metabolism
Blood Glucose
/ analysis
Blood Pressure
Blood Proteins
/ genetics
Body Mass Index
Cardiovascular Diseases
/ blood
Cholesterol, HDL
/ blood
Diabetes Mellitus
/ blood
Family Health
Female
Genetic Predisposition to Disease
Genotype
Glycated Hemoglobin
/ genetics
Glycosylation
Humans
Hyperglycemia
Hypoglycemia
/ blood
Lipids
/ blood
Lod Score
Male
Middle Aged
Nepal
Pedigree
Phenotype
Polymorphism, Single Nucleotide
Quantitative Trait Loci
Retrospective Studies
Risk Factors
Serum Albumin
/ analysis
Young Adult
Journal
Journal of diabetes research
ISSN: 2314-6753
Titre abrégé: J Diabetes Res
Pays: England
ID NLM: 101605237
Informations de publication
Date de publication:
2019
2019
Historique:
received:
17
08
2018
revised:
20
12
2018
accepted:
12
01
2019
entrez:
16
5
2019
pubmed:
16
5
2019
medline:
18
12
2019
Statut:
epublish
Résumé
Measurements of fasting glucose (FG) or glycated hemoglobin A1c (HbA1c) are two clinically approved approaches commonly used to determine glycemia, both of which are influenced by genetic factors. Obtaining accurate measurements of FG or HbA1c is not without its challenges, though. Measuring glycated serum protein (GSP) offers an alternative approach for assessing glycemia. The aim of this study was to estimate the heritability of GSP and GSP expressed as a percentage of total serum albumin (%GA) using a variance component approach and localize genomic regions (QTLs) that harbor genes likely to influence GSP and %GA trait variation in a large extended multigenerational pedigree from Jiri, Nepal (
Identifiants
pubmed: 31089471
doi: 10.1155/2019/2310235
pmc: PMC6476113
doi:
Substances chimiques
Biomarkers
0
Blood Glucose
0
Blood Proteins
0
Cholesterol, HDL
0
Glycated Hemoglobin A
0
Lipids
0
Serum Albumin
0
hemoglobin A1c protein, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2310235Subventions
Organisme : NCRR NIH HHS
ID : C06 RR020547
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY024384
Pays : United States
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