Epidemiological and clinical suspicion of congenital Zika virus infection: Serological findings in mothers and children from Brazil.
Adult
Antibodies, Neutralizing
/ blood
Antibodies, Viral
/ blood
Brazil
/ epidemiology
Child, Preschool
Diagnostic Imaging
Humans
Immunoglobulin M
/ blood
Infant
Infant, Newborn
Infectious Disease Transmission, Vertical
/ statistics & numerical data
Neutralization Tests
Phenotype
Public Health Surveillance
Serologic Tests
Zika Virus
Zika Virus Infection
/ diagnosis
congenital infection
diagnosis
flavivirus
microcephaly
neutralization test
serological tests
Journal
Journal of medical virology
ISSN: 1096-9071
Titre abrégé: J Med Virol
Pays: United States
ID NLM: 7705876
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
24
09
2018
revised:
17
04
2019
accepted:
08
05
2019
pubmed:
16
5
2019
medline:
4
6
2020
entrez:
16
5
2019
Statut:
ppublish
Résumé
The emergence of Zika virus in the Americas has caused an increase of babies born with microcephaly or other neurological malformations. The differential diagnosis of Zika infection, particularly serological diagnosis, is an important but complex issue. In this study, we describe clinical manifestations of 94 suspected cases of congenital Zika from Bahia state, Brazil, and the results of serological tests performed on children and/or their mothers at an average of 71 days after birth. Anti-Zika immunoglobulin M (IgM) antibodies were detected in 44.4% and in 7.1% of samples from mothers and children, respectively. Nearly all the IgM, and 92% of immunoglobulin G positive results were confirmed by neutralization test. Zika specific neutralizing antibodies were detected in as much as 90.4% of the cases. Moreover, dengue specific neutralizing antibodies were detected in 79.0% of Zika seropositive mothers. In conclusion, Zika IgM negative results should be considered with caution, due to a possible rapid loss of sensitivity after birth, while the NS1-based Zika IgM enzyme-linked immunosorbent assay test we have used has demonstrated to be highly specific. In a high percentage of cases, Zika specific neutralizing antibodies were detected, which are indicative of a past Zika infection, probably occurred during pregnancy in this population.
Identifiants
pubmed: 31090222
doi: 10.1002/jmv.25504
pmc: PMC6773202
doi:
Substances chimiques
Antibodies, Neutralizing
0
Antibodies, Viral
0
Immunoglobulin M
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1577-1583Informations de copyright
© 2019 The Authors. Journal of Medical Virology Published by Wiley Periodicals, Inc.
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