EUFOREA consensus on biologics for CRSwNP with or without asthma.
asthma
biologics
chronic rhinosinusitis
nasal polyps
type 2 inflammation
Journal
Allergy
ISSN: 1398-9995
Titre abrégé: Allergy
Pays: Denmark
ID NLM: 7804028
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
06
03
2019
revised:
11
04
2019
accepted:
14
04
2019
pubmed:
16
5
2019
medline:
10
9
2020
entrez:
16
5
2019
Statut:
ppublish
Résumé
Novel therapies such as type 2 targeting biologics are emerging treatment options for patients with chronic inflammatory respiratory diseases, fulfilling the needs of severely uncontrolled patients. The majority of patients with chronic rhinosinusitis with nasal polyps (CRSwNP) and over half of patients with asthma show a type 2 inflammatory signature in sinonasal mucosa and/or lungs. Importantly, both chronic respiratory diseases are frequent comorbidities, ensuring alleviation of both upper and lower airway pathology by systemic biological therapy. Type 2-targeting biologics such as anti-IgE, anti-IL4Rα, anti-IL5, and anti-IL5Rα have entered the market for selected pheno/endotypes of asthma patients and may soon also become available for CRSwNP patients. Given the high prevalence of chronic respiratory diseases and the high cost associated with biologics, patient selection is crucial in order to implement such therapies into chronic respiratory disease care pathways. The European Forum for Research and Education in Allergy and Airway Diseases (EUFOREA) organized a multidisciplinary Expert Board Meeting to discuss the positioning of biologics into the care pathways for CRSwNP patients with and without comorbid asthma.
Identifiants
pubmed: 31090937
doi: 10.1111/all.13875
pmc: PMC6972984
doi:
Substances chimiques
Biological Products
0
Types de publication
Consensus Development Conference
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2312-2319Informations de copyright
© 2019 The Authors Allergy Published by John Wiley & Sons Ltd.
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