Sex differences in behavior and neuropharmacology of zebrafish.
CNS diseases
gender differences
pharmacogenetics
sex-environment interactions
Journal
The European journal of neuroscience
ISSN: 1460-9568
Titre abrégé: Eur J Neurosci
Pays: France
ID NLM: 8918110
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
17
12
2018
revised:
27
04
2019
accepted:
08
05
2019
pubmed:
16
5
2019
medline:
22
6
2021
entrez:
16
5
2019
Statut:
ppublish
Résumé
Sex is an important variable in biomedical research. The zebrafish (Danio rerio) is increasingly utilized as a powerful new model organism in translational neuroscience and pharmacology. Mounting evidence indicates important sex differences in zebrafish behavioral and neuropharmacological responses. Here, we discuss the role of sex in zebrafish central nervous system (CNS) models, their molecular mechanisms, recent findings and the existing challenges in this field. We also emphasize the growing utility of zebrafish models in translational neuropharmacological research of sex differences, fostering future CNS drug discovery and the search for novel sex-specific therapies. Finally, we highlight the interplay between sex and environment in zebrafish models of sex-environment correlations as an important strategy of CNS disease modeling using this aquatic organism.
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2586-2603Subventions
Organisme : Russian Science Foundation
ID : 19-15-00053
Organisme : Russian Foundation for Basic Research
ID : 18-34-00996
Organisme : Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul
ID : 17/2551-0001-269-0
Informations de copyright
© 2019 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.
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