Selective laser trabeculoplasty in exfoliative glaucoma eyes with prior argon laser trabeculoplasty.


Journal

Acta ophthalmologica
ISSN: 1755-3768
Titre abrégé: Acta Ophthalmol
Pays: England
ID NLM: 101468102

Informations de publication

Date de publication:
Feb 2020
Historique:
received: 23 09 2018
accepted: 15 04 2019
pubmed: 16 5 2019
medline: 20 11 2020
entrez: 16 5 2019
Statut: ppublish

Résumé

To explore the efficacy of selective laser trabeculoplasty (SLT) within eyes with exfoliative glaucoma and history of prior argon laser trabeculoplasty (ALT). A single-centre trial consisting of 47 patients (47 eyes) with uncontrolled exfoliative glaucoma. The main outcome measure was intraocular pressure (IOP) reduction 3 and 9 months after SLT. Treatment success was defined as reduction from the preoperative IOP by 20% and 2 mmHg (<12 mmHg), 3 mmHg (12-16 mmHg) or 4 mmHg (>16 mmHg) depending on the baseline IOP. Patient age was 79.3 ± 7.6 years (mean ± SD) and gender distribution 15 males and 32 females. The mean pre-SLT IOP was 15.6 ± 5.1 (range 9-28) mmHg, and mean number of glaucoma drugs 2.0 ± 1.2. The mean interval between prior ALT and SLT was 44.0 ± 36.9 (range 11-137) months. After SLT, the mean IOP change was -2.7 ± 4.2 mmHg (-14.8 ± 23.5%) at 3 months, and -2.8 ± 3.5 mmHg (-16.3 ± 19.4%) at 9 months. Pre-SLT IOP correlated with the IOP reduction at 3 months (r = 0.530, p < 0.001) and at 9 months (r = 0.432, p = 0.007). The overall success rate was 50% at 3 months, and 42% at 9 months. At both 3 and at 9 months, the cut-off level for treatment success was achieved when preoperative IOP was 18 mmHg and above. IOP lowering effect of SLT did not correlate with the number of glaucoma drugs, age, gender or use of prostaglandin inhibitors. Neither postoperative iritis nor other adverse effects were documented during the follow-up. Selective laser trabeculoplasty is a safe and noteworthy treatment option to reduce IOP in exfoliative glaucoma eyes, especially with pre-SLT IOP over 18 mmHg.

Identifiants

pubmed: 31091010
doi: 10.1111/aos.14136
doi:

Types de publication

Clinical Trial Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

58-64

Subventions

Organisme : Paulon Säätiö
Organisme : Orionin Tutkimussäätiö
Organisme : Waldemar von Frenckell Foundation
Organisme : Finnish Ophthalmological Society
Organisme : HUS Specific Catchment Area (ERVA) Clinical Research Grants
Organisme : Nissi foundation
Organisme : Finnish Eye foundation
Organisme : Glaukooma tukisäätiö LUX

Informations de copyright

© 2019 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.

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Auteurs

Lotta Ilveskoski (L)

Helsinki Retina Research Group, University of Helsinki, Helsinki, Finland.
Department of Ophthalmology, Helsinki University Hospital, Helsinki, Finland.

Claudia Taipale (C)

Helsinki Retina Research Group, University of Helsinki, Helsinki, Finland.
Department of Ophthalmology, Helsinki University Hospital, Helsinki, Finland.

Raimo Tuuminen (R)

Helsinki Retina Research Group, University of Helsinki, Helsinki, Finland.
Kymenlaakso Central Hospital, Unit of Ophthalmology, Kotka, Finland.

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