SIRT2 Contributes to the Resistance of Melanoma Cells to the Multikinase Inhibitor Dasatinib.
melanoma, SIRT2, sirtuins, tyrosine kinase, resistance
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
14 May 2019
14 May 2019
Historique:
received:
05
04
2019
revised:
08
05
2019
accepted:
12
05
2019
entrez:
17
5
2019
pubmed:
17
5
2019
medline:
17
5
2019
Statut:
epublish
Résumé
Malignant melanoma is the most aggressive skin cancer and can only be cured if detected early. Unfortunately, later stages of the disease do not guarantee success due to the rapid rate of melanoma cell metastasis and their high resistance to applied therapies. The search for new molecular targets and targeted therapy may represent the future in the development of effective methods for combating this cancer. SIRT2 is a promising target; thus, we downregulated
Identifiants
pubmed: 31091806
pii: cancers11050673
doi: 10.3390/cancers11050673
pmc: PMC6562913
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Narodowe Centrum Nauki
ID : 2015/17/B/NZ5/00142
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
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