Annexin A2 and S100A10 as Candidate Prognostic Markers in Epithelial Ovarian Cancer.
Annexin A2
EOC
S100A10
biomarkers
epithelial ovarian cancer
immunohistochemistry
Journal
Anticancer research
ISSN: 1791-7530
Titre abrégé: Anticancer Res
Pays: Greece
ID NLM: 8102988
Informations de publication
Date de publication:
May 2019
May 2019
Historique:
received:
11
01
2019
revised:
27
03
2019
accepted:
15
04
2019
entrez:
17
5
2019
pubmed:
17
5
2019
medline:
23
5
2019
Statut:
ppublish
Résumé
Ovarian cancer (OC) is the 5th most common cancer among European women. Approximately 70-80% of OC is diagnosed at advanced stage resulting in an elevated mortality rate. The aim of this study was to examine whether Annexin A2 and S100A10 expression can be used as prognostic markers for epithelial ovarian cancer (EOC). Expression of Annexin A2 and S100A10 was evaluated in EOC tissue samples (n=303) by immunohistochemistry. The staining of the membrane, cytoplasmic and stroma was assessed according to intensity. The expression of both markers correlated to histological subtype, histological grading, International Federation of Gynecology and Obstetrics (FIGO) stage, and macro-radical surgery. Univariate Cox regression analysis showed that Annexin A2 and S100A10 in stromal tissue correlated with shorter overall survival (OS). Multivariate Cox regression analysis demonstrated no independent prognostic significance of stromal Annexin A2 expression. High expression of Annexin A2 and S100A10 in stromal tissue from EOC patients was associated with reduced OS; however, no independent prognostic value was found for any of the markers.
Sections du résumé
BACKGROUND/AIM
OBJECTIVE
Ovarian cancer (OC) is the 5th most common cancer among European women. Approximately 70-80% of OC is diagnosed at advanced stage resulting in an elevated mortality rate. The aim of this study was to examine whether Annexin A2 and S100A10 expression can be used as prognostic markers for epithelial ovarian cancer (EOC).
MATERIALS AND METHODS
METHODS
Expression of Annexin A2 and S100A10 was evaluated in EOC tissue samples (n=303) by immunohistochemistry. The staining of the membrane, cytoplasmic and stroma was assessed according to intensity.
RESULTS
RESULTS
The expression of both markers correlated to histological subtype, histological grading, International Federation of Gynecology and Obstetrics (FIGO) stage, and macro-radical surgery. Univariate Cox regression analysis showed that Annexin A2 and S100A10 in stromal tissue correlated with shorter overall survival (OS). Multivariate Cox regression analysis demonstrated no independent prognostic significance of stromal Annexin A2 expression.
CONCLUSION
CONCLUSIONS
High expression of Annexin A2 and S100A10 in stromal tissue from EOC patients was associated with reduced OS; however, no independent prognostic value was found for any of the markers.
Identifiants
pubmed: 31092442
pii: 39/5/2475
doi: 10.21873/anticanres.13367
doi:
Substances chimiques
Annexin A2
0
Biomarkers, Tumor
0
S100 Proteins
0
S100 calcium binding protein A10
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2475-2482Informations de copyright
Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.