Simian-Human Immunodeficiency Virus SHIV.CH505-Infected Infant and Adult Rhesus Macaques Exhibit Similar Env-Specific Antibody Kinetics, despite Distinct T-Follicular Helper and Germinal Center B Cell Landscapes.

Age Factors Animals Antibodies, Neutralizing / blood Antibody Formation B-Lymphocytes / immunology Disease Models, Animal Germinal Center / immunology HIV / immunology HIV Antibodies / blood HIV Infections / immunology Immunoglobulin G / blood Macaca mulatta Plasma / virology T-Lymphocytes / immunology Viral Load env Gene Products, Human Immunodeficiency Virus / immunology
SHIV SIV animal model human immunodeficiency virus macaque pediatric HIV pediatric immunology

Journal

Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724

Informations de publication

Date de publication:
01 08 2019
Historique:
received: 31 01 2019
accepted: 02 05 2019
pubmed: 17 5 2019
medline: 2 6 2020
entrez: 17 5 2019
Statut: epublish

Résumé

Global elimination of pediatric human immunodeficiency virus (HIV) infections will require the development of novel immune-based approaches, and understanding infant immunity to HIV is critical to guide the rational design of these intervention strategies. Despite their immunological immaturity, chronically HIV-infected children develop broadly neutralizing antibodies (bnAbs) more frequently and earlier than adults do. However, the ontogeny of humoral responses during acute HIV infection is poorly defined in infants and challenging to study in human cohorts due to the presence of maternal antibodies. To further our understanding of age-related differences in the development of HIV-specific immunity during acute infection, we evaluated the generation of virus-specific humoral immune responses in infant (

Identifiants

DOI: 10.1128/JVI.00168-19 PMID: 31092583 PMC: PMC6639294
pubmed: 31092583
pii: JVI.00168-19
doi: 10.1128/JVI.00168-19
pmc: PMC6639294
pii:
doi:

Substances chimiques

Antibodies, Neutralizing 0
HIV Antibodies 0
Immunoglobulin G 0
env Gene Products, Human Immunodeficiency Virus 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIAID NIH HHS
ID : UM1 AI126620
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI126619
Pays : United States
Organisme : NIH HHS
ID : P51 OD011107
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI045008
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA009111
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI131251
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI106380
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI117915
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI050410
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI100645
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE025444
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI131331
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA016086
Pays : United States
Organisme : NIH HHS
ID : K01 OD024877
Pays : United States

Informations de copyright

Copyright © 2019 American Society for Microbiology.

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Auteurs

Ashley N Nelson (AN)

Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA.
ORCID: 0000-0003-4647-7667

Ria Goswami (R)

Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA.

Maria Dennis (M)

Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA.

Joshua Tu (J)

Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA.

Riley J Mangan (RJ)

Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA.

Pooja T Saha (PT)

Gillings School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Center for AIDS Research, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

Derek W Cain (DW)

Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA.

Alan D Curtis (AD)

Center for AIDS Research, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

Xiaoying Shen (X)

Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA.
ORCID: 0000-0002-8387-3952

George M Shaw (GM)

Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Katharine Bar (K)

Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Michael Hudgens (M)

Gillings School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Center for AIDS Research, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

Justin Pollara (J)

Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA.

Kristina De Paris (K)

Center for AIDS Research, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

Koen K A Van Rompay (KKA)

California National Primate Research Center, University of California, Davis, Davis, California, USA.
ORCID: 0000-0002-7375-1337

Sallie R Permar (SR)

Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA sallie.permar@duke.edu.

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Classifications MeSH

questionsmedicales.fr › Environnement et santé publique › Santé publique › Facteurs épidémiologiques › Facteurs âges › Simian-Human Immunodeficiency Virus...
questionsmedicales.fr › Eucaryotes › Animaux › Simian-Human Immunodeficiency Virus...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps neutralisants › Simian-Human Immunodeficiency Virus...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité acquise › Immunité active › Production d'anticorps › Simian-Human Immunodeficiency Virus...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes B › Simian-Human Immunodeficiency Virus...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Simian-Human Immunodeficiency Virus...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système lymphatique › Tissu lymphoïde › Noeuds lymphatiques › Centre germinatif › Simian-Human Immunodeficiency Virus...
questionsmedicales.fr › Virus › Virus à ARN › Retroviridae › Lentivirus › Lentivirus des primates › VIH (Virus de l'Immunodéficience Humaine) › Simian-Human Immunodeficiency Virus...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps antiviraux › Anticorps antideltarétrovirus › Anticorps anti-VIH › Simian-Human Immunodeficiency Virus...
questionsmedicales.fr › Maladies du système immunitaire › Déficits immunitaires › Infections à VIH › Simian-Human Immunodeficiency Virus...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Isotypes des immunoglobulines › Immunoglobuline G › Simian-Human Immunodeficiency Virus...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca › Macaca mulatta › Simian-Human Immunodeficiency Virus...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Sang › Plasma sanguin › Simian-Human Immunodeficiency Virus...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Simian-Human Immunodeficiency Virus...
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Charge virale › Simian-Human Immunodeficiency Virus...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › Protéines virales structurales › Protéines de l'enveloppe virale › Produits du gène env › Produits du gène env du virus de l'immunodéficience humaine › Simian-Human Immunodeficiency Virus...