Clinical Importance of
Coronary artery disease
ERα mRNA expression
ESR1 gene polymorphisms
Real time PCR
Journal
Indian journal of clinical biochemistry : IJCB
ISSN: 0970-1915
Titre abrégé: Indian J Clin Biochem
Pays: India
ID NLM: 8708303
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
received:
24
01
2019
accepted:
19
03
2019
entrez:
17
5
2019
pubmed:
17
5
2019
medline:
17
5
2019
Statut:
ppublish
Résumé
The influence of Estrogen Receptor 1 (ESR1) gene -397T>C (PvuII) and -351A>G (XbaI) polymorphisms on the risk of development of coronary artery disease (CAD) in the north Indian population was analysed. We hypothesized that ESR1 gene polymorphisms may influence the susceptibility to CAD through variation in Estrogen Receptor α (ERα) expression. To assess this concept, we evaluated ERα mRNA expression in blood plasma of CAD patients. The study included hundred CAD patients who showed presence of greater than 50% luminal stenosis in at least one major coronary artery in angiography along with hundred age and sex matched healthy controls. The ESR1 polymorphisms were investigated by PCR-RFLP. Quantitative Real Time PCR was carried out for the measurement of ERα mRNA expression. The results showed that genotypic frequencies of ESR1 -397T>C and -351A>G gene polymorphisms were significantly higher in CAD patients than control subjects (
Identifiants
pubmed: 31092986
doi: 10.1007/s12291-019-00827-y
pii: 827
pmc: PMC6486943
doi:
Types de publication
Journal Article
Langues
eng
Pagination
133-142Déclaration de conflit d'intérêts
There is no conflict of interest to declare in this study.The study was conducted in accordance to GCP and ICMR guideline and approved by Institutional Ethical Committee of Maulana Azad Medical College, New Delhi, India. The study was approved by Institutional Ethical Committee of Maulana Azad Medical College, New Delhi, India.Written informed consent was obtained from each patient and healthy volunteer.
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