Sugammadex for Reversal of Neuromuscular Blockade in a Patient With Renal Failure.
neuromuscular blockade
renal failure
reversal
sugammadex
Journal
The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG
ISSN: 1551-6776
Titre abrégé: J Pediatr Pharmacol Ther
Pays: United States
ID NLM: 101089851
Informations de publication
Date de publication:
Historique:
entrez:
17
5
2019
pubmed:
17
5
2019
medline:
17
5
2019
Statut:
ppublish
Résumé
Residual neuromuscular blockade following the use of non-depolarizing neuromuscular blocking agents (NMBAs) can lead to postoperative respiratory complications, including oxygen desaturation, atelectasis, and pneumonia. Sugammadex rapidly reverses steroidal NMBAs by encapsulating them in a highly stable water-soluble complex. This NMBA-sugammadex complex then undergoes renal elimination. In patients with renal insufficiency or failure, concern has been expressed regarding the elimination of the NMBA-sugammadex complex. We present a 19-year-old patient with renal failure who received sugammadex for reversal of neuromuscular blockade. The use of sugammadex in patients with renal dysfunction is discussed and safety concerns are reviewed.
Identifiants
pubmed: 31093024
doi: 10.5863/1551-6776-24.3.238
pmc: PMC6510526
doi:
Types de publication
Case Reports
Langues
eng
Pagination
238-241Références
Anesth Analg. 2000 Jul;91(1):237-41
pubmed: 10866919
Angew Chem Int Ed Engl. 2002 Jan 18;41(2):266-70
pubmed: 12491405
Anesth Analg. 2005 Nov;101(5):1356-61
pubmed: 16243994
Anesthesiology. 2006 Jan;104(1):158-69
pubmed: 16394702
Am J Respir Crit Care Med. 2007 Jan 1;175(1):9-15
pubmed: 17023729
Anesth Analg. 2007 Mar;104(3):569-74
pubmed: 17312210
Anesth Analg. 2007 Mar;104(3):575-81
pubmed: 17312211
Anesth Analg. 2007 Mar;104(3):585-6
pubmed: 17312213
Br J Anaesth. 2008 Oct;101(4):492-7
pubmed: 18653492
Anesth Analg. 2010 Jan 1;110(1):64-73
pubmed: 19713265
Br J Anaesth. 2010 Jan;104(1):31-9
pubmed: 20007792
Anesth Analg. 2010 Jul;111(1):120-8
pubmed: 20442260
Eur J Anaesthesiol. 2010 Oct;27(10):874-81
pubmed: 20683334
Br J Anaesth. 2012 Sep;109(3):382-90
pubmed: 22732111
Anesth Analg. 2012 Oct;115(4):873-9
pubmed: 22763904
Indian J Anaesth. 2013 Jan;57(1):46-51
pubmed: 23716766
Saudi J Anaesth. 2014 Apr;8(2):153-4
pubmed: 24843323
Br J Anaesth. 2015 May;114(5):777-84
pubmed: 25829395
Eur J Anaesthesiol. 2015 Oct;32(10):681-6
pubmed: 26225497
Eur J Anaesthesiol. 2016 May;33(5):383-6
pubmed: 26351827
Med Sci Monit. 2016 Mar 10;22:803-9
pubmed: 26963316
Paediatr Anaesth. 2017 Feb;27(2):118-125
pubmed: 27859917
Anaesthesia. 2017 Jun;72(6):765-777
pubmed: 28654173
Ann Card Anaesth. 2017 Jul-Sep;20(3):376-378
pubmed: 28701612
Anesthesiology. 1986 Aug;65(2):165-9
pubmed: 2874752
Anaesthesia. 1993 Oct;48(10):873-5
pubmed: 8238829