Allelic Switching of
Journal
International journal of genomics
ISSN: 2314-436X
Titre abrégé: Int J Genomics
Pays: United States
ID NLM: 101605206
Informations de publication
Date de publication:
2019
2019
Historique:
received:
01
10
2018
revised:
28
01
2019
accepted:
07
02
2019
entrez:
17
5
2019
pubmed:
17
5
2019
medline:
17
5
2019
Statut:
epublish
Résumé
Allele-specific expression (ASE) is found in approximately 20-30% of human genes. During tumorigenesis, ASE changes due to somatic alterations that change the regulatory landscape. In colorectal cancer (CRC), many chromosomes show frequent gains or losses while homozygosity of chromosome 7 is rare. We hypothesized that genes essential to survival show allele-specific expression (ASE) on both alleles of chromosome 7. Using a panel of 21 recently established low-passage CRC cell lines, we performed ASE analysis by hybridizing DNA and cDNA to Infinium HumanExome-12 v1 BeadChips containing cSNPs in 392 chromosome 7 genes. The results of this initial analysis were extended and validated in a set of 89 paired normal mucosa and CRC samples. We found that 14% of genes showed ASE in one or more cell lines and identified
Identifiants
pubmed: 31093489
doi: 10.1155/2019/1287671
pmc: PMC6481143
doi:
Types de publication
Journal Article
Langues
eng
Pagination
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