Massive uric acid crystalluria and cylinduria in a dog after l-asparaginase treatment for lymphoma.
chemotherapy
hyperuricemia
lymphoma
uric acid crystals
urinalysis
Journal
Veterinary clinical pathology
ISSN: 1939-165X
Titre abrégé: Vet Clin Pathol
Pays: United States
ID NLM: 9880575
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
received:
19
06
2018
revised:
31
07
2018
accepted:
14
08
2018
pubmed:
17
5
2019
medline:
6
2
2020
entrez:
17
5
2019
Statut:
ppublish
Résumé
A 10-year-old golden retriever bitch was treated for diarrhea and vomiting that lasted about 1 month without a specific diagnosis until a hepatic biopsy provided a histopathologic diagnosis of lymphoma. The dog was referred to the Swedish University of Agricultural Science and treated with one dose of l-asparaginase. The day after chemotherapy, the urine was dark yellow, very turbid, and had large amounts of small amorphous crystals and many casts made of similar appearing material identified by infrared spectroscopy to be 100% uric acid dihydrate. Serum uric acid was elevated at 224 μmol/L (RI 0-59). The dog's illness became worse after chemotherapy. Lymphoma treatment was not continued, and the dog was euthanized 9 days after the l-asparaginase treatment. Among other problems were persistent proteinuria with a urine protein-to-creatinine ratio of 2.3 and severe hypoalbuminemia. Serum protein electrophoresis performed 3 weeks prior to chemotherapy indicated hyperproteinemia (total protein 78 g/L) having a biclonal gammopathy with 35 g/L β-2 globulins and 11 g/L γ globulins. Despite prominent cylinduria and crystalluria, the patient did not develop azotemia or isosthenuria.
Substances chimiques
Uric Acid
268B43MJ25
Asparaginase
EC 3.5.1.1
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
425-428Informations de copyright
© 2019 American Society for Veterinary Clinical Pathology.
Références
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