1D network simulations for evaluating regional flow and pressure distributions in healthy and asthmatic human lungs.
Adult
Airway Resistance
/ physiology
Asthma
/ physiopathology
Computer Simulation
Exhalation
/ physiology
Female
Four-Dimensional Computed Tomography
/ methods
Functional Residual Capacity
/ physiology
Humans
Hydrodynamics
Inhalation
/ physiology
Lung
/ physiology
Male
Models, Biological
Respiration
Respiratory Function Tests
/ methods
airway diameter
airway resistance
boundary condition
lung compliance
lung hysteresis
Journal
Journal of applied physiology (Bethesda, Md. : 1985)
ISSN: 1522-1601
Titre abrégé: J Appl Physiol (1985)
Pays: United States
ID NLM: 8502536
Informations de publication
Date de publication:
01 07 2019
01 07 2019
Historique:
pubmed:
17
5
2019
medline:
30
9
2020
entrez:
17
5
2019
Statut:
ppublish
Résumé
This study aimed to introduce a one-dimensional (1D) computational fluid dynamics (CFD) model for airway resistance and lung compliance to examine the relationship between airway resistance, pressure, and regional flow distribution. We employed five healthy and five asthmatic subjects who had dynamic computed tomography (CT) scans (4D CT) along with two static scans at total lung capacity and functional residual capacity. Fractional air-volume change (
Identifiants
pubmed: 31095459
doi: 10.1152/japplphysiol.00016.2019
pmc: PMC6692748
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
122-133Subventions
Organisme : FDA HHS
ID : U01 FD005837
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL114494
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK054759
Pays : United States
Organisme : NCRR NIH HHS
ID : S10 RR022421
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL112986
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES005605
Pays : United States
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