Imported strongyloidiasis: Data from 1245 cases registered in the +REDIVI Spanish Collaborative Network (2009-2017).
Adolescent
Adult
Aged
Aged, 80 and over
Albendazole
/ therapeutic use
Animals
Anthelmintics
/ therapeutic use
Child
Child, Preschool
Emigrants and Immigrants
/ statistics & numerical data
Eosinophilia
/ etiology
Female
Humans
Infant
Ivermectin
/ therapeutic use
Male
Middle Aged
Retrospective Studies
South America
Spain
/ epidemiology
Strongyloides stercoralis
/ drug effects
Strongyloidiasis
/ complications
Travel
Young Adult
Journal
PLoS neglected tropical diseases
ISSN: 1935-2735
Titre abrégé: PLoS Negl Trop Dis
Pays: United States
ID NLM: 101291488
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
05
02
2019
accepted:
17
04
2019
revised:
29
05
2019
pubmed:
17
5
2019
medline:
28
10
2019
entrez:
17
5
2019
Statut:
epublish
Résumé
Imported strongyloidiasis is increasingly being diagnosed in non-endemic areas. The aim of this study was to describe the epidemiological, clinical and microbiological characteristics of patients with imported strongyloidiasis in Spain. This is an observational retrospective study that included all patients diagnosed of strongyloidiasis registered in the +REDIVI Collaborative Network from 2009 to 2017. Demographic, epidemiological and clinical information was collected from the +REDIVI database, and extra information regarding microbiological techniques, treatment and follow-up was requested to participant centers. Overall, 1245 cases were included. Most of them were immigrants (66.9%), and South America was the most frequent area of origin. Detection of larvae in stool samples was observed in 21.9% of the patients, and serological tests allowed making the diagnosis in the rest of the cases. Eosinophilia was present in 82.2% of cases. Treatment with ivermectin (compared with albendazole) was the most strongly associated factor to achieve the cure (OR 2.34). Given the long latency of the infection and the risk of developing a severe presentation, screening of S. stercoralis infection should be mandatory in patients coming from or had traveling to endemic areas, especially in those with immunosuppressant conditions.
Sections du résumé
BACKGROUND
Imported strongyloidiasis is increasingly being diagnosed in non-endemic areas. The aim of this study was to describe the epidemiological, clinical and microbiological characteristics of patients with imported strongyloidiasis in Spain.
METHODOLOGY
This is an observational retrospective study that included all patients diagnosed of strongyloidiasis registered in the +REDIVI Collaborative Network from 2009 to 2017. Demographic, epidemiological and clinical information was collected from the +REDIVI database, and extra information regarding microbiological techniques, treatment and follow-up was requested to participant centers.
FINDINGS
Overall, 1245 cases were included. Most of them were immigrants (66.9%), and South America was the most frequent area of origin. Detection of larvae in stool samples was observed in 21.9% of the patients, and serological tests allowed making the diagnosis in the rest of the cases. Eosinophilia was present in 82.2% of cases. Treatment with ivermectin (compared with albendazole) was the most strongly associated factor to achieve the cure (OR 2.34).
CONCLUSIONS
Given the long latency of the infection and the risk of developing a severe presentation, screening of S. stercoralis infection should be mandatory in patients coming from or had traveling to endemic areas, especially in those with immunosuppressant conditions.
Identifiants
pubmed: 31095570
doi: 10.1371/journal.pntd.0007399
pii: PNTD-D-19-00166
pmc: PMC6541302
doi:
Substances chimiques
Anthelmintics
0
Ivermectin
70288-86-7
Albendazole
F4216019LN
Types de publication
Journal Article
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0007399Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist
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