Ophthalmologic evaluation of severely obese patients undergoing bariatric surgery: A pilot, monocentric, prospective, open-label study.
Adolescent
Adult
Aged
Bariatric Surgery
Eye Diseases
/ prevention & control
Glaucoma
/ etiology
Humans
Intraocular Pressure
Macular Degeneration
/ etiology
Middle Aged
Obesity
/ complications
Ophthalmology
/ methods
Optic Disk
/ injuries
Pilot Projects
Prospective Studies
Tomography, Optical Coherence
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2019
2019
Historique:
received:
03
12
2018
accepted:
18
04
2019
entrez:
17
5
2019
pubmed:
17
5
2019
medline:
28
1
2020
Statut:
epublish
Résumé
The aim of this study was to investigate the pathogenic role of obesity on blinding eye diseases in a population of severely obese patients with no history of eye diseases, and to verify whether weight loss induced by bariatric surgery may have a protective effect. This was a pilot, monocentric, prospective, and open label study conducted at the University Hospital of Pisa. Fifty-seven severely obese patients with a mean body mass index value of 44.1 ± 6 kg/m2 were consecutively recruited and received a complete ophthalmological evaluation and optical coherence tomography. Twenty-nine patients who underwent gastric bypass were evaluated also 3 months, and 1 year after surgery. At baseline, blood pressure value were directly and significantly related to intraocular pressure values (p<0.05, R = 0.35). Blood pressure values were also significantly and inversely related to retinal nerve fiber layer thickness, particularly in the temporal sector (RE p<0.05 r-0.30; LE p<0.01, R = -0.43). Moreover, minimum foveal thickness values were significantly and inversely associated with body mass index (RE p<0.02, R = -0.40; LE p<0.02, R = -0.30). A significant reduction of body mass index (p<0.05) and a significant (p<0.05) improvement of blood pressure was observed three months and one year after gastric bypass, which were significantly associated with an increase in retinal nerve fiber layer thickness and minimum foveal thickness values in both eyes (p<0.05). The results of this study suggest that obese patients may have a greater susceptibility to develop glaucomatous optic nerve head damage and age-related macular degeneration. Moreover, weight reduction and improvement of comorbidities obtained by bariatric surgery may be effective in preventing eye disease development by improving retinal nerve fiber layer and foveal thickness.
Identifiants
pubmed: 31095581
doi: 10.1371/journal.pone.0216351
pii: PONE-D-18-34137
pmc: PMC6522100
doi:
Banques de données
Dryad
['10.5061/dryad.1g6vm34']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0216351Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Ophthalmol Ther. 2018 Jun;7(1):19-31
pubmed: 29423897
Medicine (Baltimore). 2015 Jun;94(23):e947
pubmed: 26061324
Invest Ophthalmol Vis Sci. 2010 May;51(5):2644-7
pubmed: 20007831
Obes Surg. 2015 Jan;25(1):167-73
pubmed: 25425087
Ophthalmology. 2012 Nov;119(11):2245-53
pubmed: 22796305
Vojnosanit Pregl. 2013 May;70(5):469-76
pubmed: 23789286
Korean J Ophthalmol. 2013 Aug;27(4):268-75
pubmed: 23908573
PLoS One. 2013 Oct 11;8(10):e77180
pubmed: 24146967
Am J Ophthalmol. 2017 Jan;173:23-33
pubmed: 27702621
Eye (Lond). 2011 Jun;25(6):784-93
pubmed: 21436849
Lancet. 2014 Aug 30;384(9945):766-81
pubmed: 24880830
Obes Rev. 2017 Mar;18(3):309-316
pubmed: 28085992
Biochem Biophys Res Commun. 2003 Aug 22;308(2):346-52
pubmed: 12901875
Obes Surg. 2017 Feb;27(2):513-521
pubmed: 27981458
Invest Ophthalmol Vis Sci. 2014 Apr 21;55(4):2592-8
pubmed: 24667857
Int J Mol Sci. 2014 Dec 26;16(1):378-400
pubmed: 25548896
Br J Ophthalmol. 2018 Oct;102(10):1402-1406
pubmed: 29331952
Ophthalmology. 2014 Sep;121(9):1756-65
pubmed: 24813632
Indian J Ophthalmol. 2018 Jul;66(7):976-983
pubmed: 29941743
J Glaucoma. 2016 May;25(5):e509-13
pubmed: 26766402
Eur Rev Med Pharmacol Sci. 2016 Mar;20(5):886-91
pubmed: 27010146
Acta Med Okayama. 2014;68(1):27-34
pubmed: 24553486
PLoS One. 2016 Jan 05;11(1):e0146057
pubmed: 26731527
Arq Bras Oftalmol. 2017 Jun;80(3):143-147
pubmed: 28832736
Int J Ophthalmol. 2015 Apr 18;8(2):403-6
pubmed: 25938064
Ophthalmology. 2005 Apr;112(4):609-16
pubmed: 15808252
Am J Ophthalmol. 2009 Aug;148(2):266-71
pubmed: 19427616
Arch Ophthalmol. 1995 Jul;113(7):918-24
pubmed: 7605285
Prog Retin Eye Res. 2016 Sep;54:64-102
pubmed: 27156982
J Endocrinol Invest. 2019 Feb;42(2):117-128
pubmed: 29730732
Surg Obes Relat Dis. 2016 Jul;12(6):1186-91
pubmed: 27178605
Br J Ophthalmol. 2005 Mar;89(3):284-7
pubmed: 15722304
Acta Ophthalmol. 2018 Aug;96(5):e592-e595
pubmed: 29488346
Surv Ophthalmol. 2007 Mar-Apr;52(2):180-95
pubmed: 17355856
Br J Ophthalmol. 2014 Jun;98(6):721-5
pubmed: 24307714
PLoS One. 2018 May 22;13(5):e0197682
pubmed: 29787603
Arch Ophthalmol. 2001 Sep;119(9):1259-65
pubmed: 11545630
Ophthalmology. 2010 Aug;117(8):1521-9
pubmed: 20382429